1-(tert-butoxycarbonyl)-3-hydroxypiperidine-4-carboxylic acid

Base Information

• Chemical Name: 1-(tert-butoxycarbonyl)-3-hydroxypiperidine-4-carboxylic acid
• CAS No.: 1260876-51-4
• Molecular Formula: C₁₁H₁₉NO₅
• Molecular Weight: 245.276
• Hs Code.: 2933399090
• Mol file: 1260876-51-4.mol

Synonyms:1-(tert-butoxycarbonyl)-3-hydroxypiperidine-4-carboxylic acid

Chemical Property of 1-(tert-butoxycarbonyl)-3-hydroxypiperidine-4-carboxylic acid

Chemical Property:

• PSA: 87.07000
• LogP: 0.62680

Purity/Quality:

95% ^*data from raw suppliers

1-(Tert-Butoxycarbonyl)-3-Hydroxypiperidine-4-CarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(tert-butoxycarbonyl)-3-hydroxypiperidine-4-carboxylic acid

There total 4 articles about 1-(tert-butoxycarbonyl)-3-hydroxypiperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.2%

1-(tert-butyl) 4-ethyl (3S,4R)-3-hydroxypiperidine-1,4-dicarboxylate (217488-49-8) → (3S,4R)-1-tert-butoxycarbonyl-3-hydroxy-piperidine-4-carboxylic acid (1260876-51-4)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 30 ℃; for 12h; Inert atmosphere;

Reference yield:

3-hydroxypiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (71233-28-8,217488-49-8) → 1-tert-butoxycarbonyl-3-hydroxypiperidine-4-carboxylic acid (1260876-51-4)

Guidance literature:

With methanol; sodium hydroxide; at 30 ℃; for 1h;

Reference yield:

C11H17NO5 → 1-tert-butoxycarbonyl-3-hydroxypiperidine-4-carboxylic acid (1260876-51-4)

Guidance literature:

With Raney Ni; In tetrahydrofuran;

upstream raw materials:

ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate

3-hydroxypiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

1-(tert-butyl) 4-ethyl (3S,4R)-3-hydroxypiperidine-1,4-dicarboxylate

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