(3r,4r)-rel-3-amino-1-boc-4-fluoropiperidine

Base Information

• Chemical Name: (3r,4r)-rel-3-amino-1-boc-4-fluoropiperidine
• CAS No.: 1273567-30-8
• Molecular Formula: C₁₀H₁₉FN₂O₂
• Molecular Weight: 218.271
• Mol file: 1273567-30-8.mol

Synonyms:(3r,4r)-rel-3-amino-1-boc-4-fluoropiperidine;(3R,4R)-rel-tert-Butyl 3-amino-4-fluoropiperidine-1-carboxylate;tert-butyl trans-3-amino-4-fluoropiperidine-1-carboxylate

Chemical Property of (3r,4r)-rel-3-amino-1-boc-4-fluoropiperidine

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

(3R,4R)-rel-3-Amino-1-Boc-4-fluoropiperidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3r,4r)-rel-3-amino-1-boc-4-fluoropiperidine

There total 5 articles about (3r,4r)-rel-3-amino-1-boc-4-fluoropiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-tert-butyl 3-azido-4-fluoropiperidine-1-carboxylate → cis-tert-butyl 3-amino-4-fluoropiperidine-1-carboxylate (1273567-30-8,1334414-00-4,1700611-18-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1h; under 760.051 Torr;

Reference yield:

racemic trans-tert-butyl 4-fluoro-3-hydroxypiperidine-1-carboxylate (1174020-46-2,1941213-08-6,2306248-33-7,955028-82-7,1314641-02-5) → cis-tert-butyl 3-amino-4-fluoropiperidine-1-carboxylate (1273567-30-8,1334414-00-4,1700611-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 18 h / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 18 h / Heating

3: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C / 760.05 Torr

With pyridine; sodium azide; hydrogen; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;

Reference yield:

trans-tert-butyl 4-fluoro-3-(tosyloxy)piperidine-1-carboxylate → cis-tert-butyl 3-amino-4-fluoropiperidine-1-carboxylate (1273567-30-8,1334414-00-4,1700611-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h / Heating

2: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C / 760.05 Torr

With sodium azide; hydrogen; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

racemic trans-tert-butyl 4-fluoro-3-hydroxypiperidine-1-carboxylate

tert-butyl 1,2,3,4-tetrahydro-1-pyridinecarboxylate

tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate

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