RAS-2410 hydrochloride

Base Information

• Chemical Name: RAS-2410 hydrochloride
• CAS No.: 1187075-34-8
• Molecular Formula: C16H19N3O4S.HCl
• Molecular Weight: 385.871
• Mol file: 1187075-34-8.mol

Synonyms:4SC-201 hydrochloride;RAS 2410 hydrochloride;RAS2410 hydrochloride;RAS-2410 hydrochloride;ResMinostat (hydrochloride);(2E)-3-[1-[[4-[(Dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide hydrochloride (1:1)

Chemical Property of RAS-2410 hydrochloride

Chemical Property:

• PSA: 100.02000
• LogP: 3.57900
• Solubility.: Soluble in DMSO

Purity/Quality:

99%, ^*data from raw suppliers

Resminostathydrochloride(4SC-201) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Resminostat is an orally bioavailable inhibitor of histone deacetylase 1 (HDAC1), HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells. It abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 μM). Resminostat displays synergistic effects when combined with melphalan and the proteasome inhibitors bortezomib and S-2209. It dose-dependently inhibits HDAC activity in vivo.

Technology Process of RAS-2410 hydrochloride

There total 1 articles about RAS-2410 hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-[1-(4-dimethylaminomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-acryloyl chloride hydrochloride (1187075-38-2) → (E)-3-[1-(4-dimethylaminomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]N-hydroxy-acrylamide hydrochloride (1187075-34-8)

Guidance literature:

With hydroxylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; at 18 - 30 ℃; Industry scale;

upstream raw materials:

(E)-3-[1-(4-dimethylaminomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-acryloyl chloride hydrochloride

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