Decladinose Roxithromycin (Roxithromycin Impurity B)

Base Information

Chemical Name:Decladinose Roxithromycin (Roxithromycin Impurity B)
CAS No.:214902-82-6
Molecular Formula:C33H62N2O12
Molecular Weight:678.861
Hs Code.:
Mol file:214902-82-6.mol

Synonyms:Decladinose Roxithromycin (Roxithromycin Impurity B);(9E)-3-O-De(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)erythroMycin 9-[O-[(2-Methoxyethoxy)Methyl]oxiMe];(9E)-3-O-de(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)erythroMycin9-[O-[(2-Methoxyethoxy)Methyl]oxiMe];DecladinoseroxithroMycin;RoxithroMycin IMpurity B

Suppliers and Price of Decladinose Roxithromycin (Roxithromycin Impurity B)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 23 raw suppliers

Chemical Property of Decladinose Roxithromycin (Roxithromycin Impurity B)

Chemical Property:

Melting Point:88-91°C
Boiling Point:773.9±70.0 °C(Predicted)
PKA:13.02±0.70(Predicted)
PSA：189.20000
Density:1.24±0.1 g/cm3(Predicted)
LogP:1.28440
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Solubility.:DMSO (Slightly), Methanol (Sparingly), Water (Slightly)

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Roxithromycin impurity B. The inactive metabolite (M1) of Roxithromycin. Roxithromycin

Technology Process of Decladinose Roxithromycin (Roxithromycin Impurity B)

There total 1 articles about Decladinose Roxithromycin (Roxithromycin Impurity B) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 80214-83-1
roxithromycin

: 214902-82-6
Decladinoseroxithromycin

Guidance literature:: With hydrogenchloride; water; In methanol; at 20 ℃; for 12h;

Reference yield: 92.0%

: 108-24-7
acetic anhydride

: 214902-82-6
Decladinoseroxithromycin

: 214902-67-7
5-(3,4,6-trideoxy-2-O-acetyl-3-dimethylamino-β-D-xylo-hexopyranosyloxy)-3,6,11,12-tetrahydroxy-9-(2-methoxyethoxy)methoxyimino-2,4,6,8,10,12-hexamethylpentadecan-13-olide

Guidance literature:: With sodium carbonate; In dichloromethane; at 20 ℃; for 5.5h;

Reference yield:

: 214902-82-6
Decladinoseroxithromycin

: (1R,2R,5R,6S,7R,8S,10R,12R,13R,14R)-13-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-5-ethyl-1,6,7-trihydroxy-2,6,8,10,12,14-hexamethyl-4,15-dioxa-bicyclo[10.2.1]pentadecane-3,9-dione 9-[O-(2-methoxy-ethoxymethyl)-oxime]

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / K₂CO₃ / acetone / 24 h / Ambient temperature

2: 52 percent / Jones reagent / acetone / 1.5 h / 0 °C

3: 77 percent / MeOH / 24 h / Ambient temperature

With methanol; jones reagent; potassium carbonate; In acetone;
DOI:10.1021/jm980240d