Technology Process of (2R)-2-(2-FLUOROPHENYL)PYRROLIDINE
There total 2 articles about (2R)-2-(2-FLUOROPHENYL)PYRROLIDINE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; 2,3,4,5,6-pentahydroxy-hexanal; nicotinamide adenine dinucleotide phosphate;
In
aq. phosphate buffer; water; dimethyl sulfoxide;
at 30 ℃;
for 24h;
pH=7;
enantioselective reaction;
Enzymatic reaction;
DOI:10.1021/acs.orglett.0c00802
- Guidance literature:
-
With
pyridoxal 5'-phosphate; MetAlaPheSerAlaAspThrProGluIleValTyrThrHisAspThrGlyLeuAspTyrIlyThrTyrSerAspTyrGluLeuAspProAlaAsnProLeuAlaGlyGlyAlaAlaTrpIleGluGlyAlaPheValProProSerGluAlaArgIleSerIlePheAspGlnGlyPheTyrThrSerAspAlaThrTyrThrThrPheHisValTrpAsnGlyAsnAlaPheArgLeuGlyAspHisIleGluArgLeuPheSerAsnAlaGluSerIleArgLeuIleProProLeuThrGlnAspGluValLysGluIleAlaLeuGluLeuValAlaLysThrGluLeuArgGluAlaIleValSerValSerIleThrArgGlyTyrSerSerThrProPheGluArgAspIleLysHisArgProGlnValTyrMetTyrAlaValProTyrGlnTrpIleValProPheAspArgIleArgAspGlyValHisAlaMetValAlaGlnSerValArgArgSerProArgSerSerIleAspProGlnValLysAsnPheGlnTrpGlyAspLeuIleArgAlaIleGlnGluThrHisAspArgGlyPheGluLeuProLeuLeuLeuAspCysAspGlyLeuLeuAlaGluGlyProGlyPheAsnValValValIleLysAspGlyValValArgSerProGlyArgAlaAlaLeuProGlyIleThrArgLysThrValLeuGluIleAlaGluSerLeuGlyHisGluAlaIleLeuAlaAspIleThrProAlaGluLeuTyrAspAlaAspGluValLeuGlyCysSerThrGlyGlyGlyValTrpProPheValSerValAspGlyAsnSerIleSerAspGlyValProGlyProValThrGlnSerIleIleArgArgTyrTrpGluLeuAsnValGluProSerSerLeuLeuThrProValGlnTyr; isopropylamine hydrochloride;
In
water; dimethyl sulfoxide;
at 45 ℃;
for 48h;
pH=8.5;
Enzymatic reaction;
- Guidance literature:
-
With
triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
dichloromethane;
at 20 ℃;
for 16h;
DOI:10.1016/j.bmcl.2013.01.062
