5-Bromo-2-methoxybenzodifluoride

Base Information

• Chemical Name: 5-Bromo-2-methoxybenzodifluoride
• CAS No.: 1261512-49-5
• Molecular Formula: C₈H₇BrF₂O
• Molecular Weight: 237.044
• Hs Code.: 2909309090
• Mol file: 1261512-49-5.mol

Synonyms:5-Bromo-2-methoxybenzodifluoride;4-Bromo-2-difluoromethylanisole

Chemical Property of 5-Bromo-2-methoxybenzodifluoride

Chemical Property:

• PSA: 9.23000
• LogP: 3.39530

Purity/Quality:

≥99% ^*data from raw suppliers

4-Bromo-2-(difluoromethyl)-1-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-methoxybenzodifluoride

There total 2 articles about 5-Bromo-2-methoxybenzodifluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

5-bromo-2-methoxybenzaldehyde (25016-01-7) → 4-bromo-2-(difluoromethyl)-1-methoxybenzene (1261512-49-5)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 25 ℃; for 18h;

Reference yield:

5-bromosalicyclaldehyde (1761-61-1) → 4-bromo-2-(difluoromethyl)-1-methoxybenzene (1261512-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 25 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 18 h / 25 °C

With diethylamino-sulfur trifluoride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 76.0%

(R)-benzyl 3,8,8,9,9-pentamethyl-4-oxo-2,7-dioxa-3-aza-8-siladecane-5-ylcarbamate (160349-51-9) + 4-bromo-2-(difluoromethyl)-1-methoxybenzene (1261512-49-5) → C25H33F2NO5Si

Guidance literature:

4-bromo-2-(difluoromethyl)-1-methoxybenzene; With n-butyllithium; In tetrahydrofuran; at -60 ℃; for 0.5h; Inert atmosphere;

(R)-benzyl 3,8,8,9,9-pentamethyl-4-oxo-2,7-dioxa-3-aza-8-siladecane-5-ylcarbamate; In tetrahydrofuran; at -60 ℃; for 1h;

upstream raw materials:

5-bromo-2-methoxybenzaldehyde

5-bromosalicyclaldehyde

Refernces

• 1、 -. "GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES". Paragraph 000550. . Retrieved 2015/04/15.