10-hydroxy-4-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline

Base Information

• Chemical Name: 10-hydroxy-4-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline
• CAS No.: 109062-23-9
• Molecular Formula: C₁₆H₂₃NO
• Molecular Weight: 245.365
• Hs Code.: 2933990090
• Mol file: 109062-23-9.mol

Synonyms:10-hydroxy-4-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline

Chemical Property of 10-hydroxy-4-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline

Chemical Property:

• Vapor Pressure: 5.71E-05mmHg at 25°C
• Boiling Point: 336.5°Cat760mmHg
• Flash Point: 142.1°C
• PSA: 23.47000
• Density: 1.058g/cm³
• LogP: 3.23430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10-hydroxy-4-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline

There total 4 articles about 10-hydroxy-4-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

(4aR,10bS)-10-methoxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzoquinoline (109062-22-8) → cis-(4aR,10bS)-10-hydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline (109062-23-9)

Guidance literature:

With hydrogen bromide; for 2h; Heating;

DOI:10.1021/jm00392a007

Reference yield:

cis-10-methoxy-1,2,3,4,4a,5,6,10b-octahydrobenzoquinoline hydrochloride (82171-88-8) → cis-(4aR,10bS)-10-hydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline (109062-23-9)

Guidance literature:

Multi-step reaction with 4 steps

2: 96 percent / Et₃N / CH₂Cl₂ / 1 h

3: 71 percent / LiAlH₄ / diethyl ether / 1 h

4: 44 percent / 48percent aq. HBr / 2 h / Heating

With lithium aluminium tetrahydride; hydrogen bromide; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1021/jm00392a007

Reference yield:

(4aR,10bS)-10-methoxy-4-(1-oxopropyl)-1,2,3,4,4a,5,6,10b-octahydrobenzoquinoline (109062-27-3) → cis-(4aR,10bS)-10-hydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline (109062-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / LiAlH₄ / diethyl ether / 1 h

2: 44 percent / 48percent aq. HBr / 2 h / Heating

With lithium aluminium tetrahydride; hydrogen bromide; In diethyl ether;

DOI:10.1021/jm00392a007

upstream raw materials:

(4aR,10bS)-10-methoxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzoquinoline

cis-10-methoxy-1,2,3,4,4a,5,6,10b-octahydrobenzoquinoline hydrochloride

(4aR,10bS)-10-methoxy-4-(1-oxopropyl)-1,2,3,4,4a,5,6,10b-octahydrobenzoquinoline

cis-(4aR,10bS)-10-methoxy-1,2,3,4,4a,5,6,10b-octahydrobenzoquinoline hydrochloride

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