5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine

Base Information

Chemical Name:5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
CAS No.:1527503-11-2
Molecular Formula:
Molecular Weight:329.44
Hs Code.:
Mol file:1527503-11-2.mol

Synonyms:5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine;A-366;A-336

Suppliers and Price of 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
A366 ≥98%(HPLC)
10
$ 212.00

Tocris
A366 ≥98%(HPLC)
50
$ 891.00

DC Chemicals
A-366 >98%
1 g
$ 2300.00

DC Chemicals
A-366 >98%
100 mg
$ 550.00

ChemScene
A-366 98.02%
5mg
$ 78.00

ChemScene
A-366 98.02%
10mg
$ 132.00

ChemScene
A-366 98.02%
50mg
$ 528.00

Chemenu
5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98%
250mg
$ 1029.00

Chemenu
5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98%
100mg
$ 636.00

Chemenu
5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98%
50mg
$ 374.00

Total 15 raw suppliers

Chemical Property of 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine

Chemical Property:

Boiling Point:533.6±60.0 °C(Predicted)
PKA:10.18±0.20(Predicted)
Density:1.29±0.1 g/cm3(Predicted)
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

A366 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A-366 acts as a potent peptide-competitive inhibitor of the lysine methyltransferase G9a. 1000 fold selectivity over other methyl transferases.

Technology Process of 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine

There total 5 articles about 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1527503-24-7
1-(5-methoxy-2-nitro-4-(3-(pyrrolidin-1-yl)propoxy)phenyl)cyclobutanecarbonitrile

: 1527503-11-2
A-366

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic acid; at 80 ℃; for 5h;
DOI:10.1021/ml400496h

Reference yield:

: 1700-29-4
2-(4-(benzyloxy)-3-methoxyphenyl)acetonitrile

: 1527503-11-2
A-366

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 72 h / 20 °C / Inert atmosphere

2: nitric acid; acetic acid; acetic anhydride / 0.33 h / 0 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 70 °C

4: potassium carbonate / acetonitrile / 3 h / 100 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen; acetic acid / 5 h / 80 °C

With palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; nitric acid; acetic anhydride; potassium carbonate; acetic acid; sodium hydroxide; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ml400496h

Reference yield:

: 1260902-74-6
1-(4-(benzyloxy)-3-methoxyphenyl)cyclobutanecarbonitrile

: 1527503-11-2
A-366

Guidance literature:: Multi-step reaction with 4 steps

1: nitric acid; acetic acid; acetic anhydride / 0.33 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 70 °C

3: potassium carbonate / acetonitrile / 3 h / 100 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen; acetic acid / 5 h / 80 °C

With palladium 10% on activated carbon; hydrogen; nitric acid; acetic anhydride; potassium carbonate; acetic acid; In ethanol; acetonitrile;
DOI:10.1021/ml400496h