(S)-1-[2-(Diphenylphosphino)phenyl]ethylamine, min. 97%

Base Information

• Chemical Name: (S)-1-[2-(Diphenylphosphino)phenyl]ethylamine, min. 97%
• CAS No.: 913196-43-7
• Molecular Formula: C20H20NP
• Molecular Weight: 305.359
• Mol file: 913196-43-7.mol

Synonyms:(S)-1-[2-(Diphenylphosphino)phenyl]ethylamine, min. 97%;(S)-1-[2-(Diphenylphosphino)phenyl]ethylaMine;(S)-(-)-1-[2-(Diphenylphosphino)phenyl]ethylaMine, 97+%;(S)-1-[2-(Diphenylphosphino)phenyl]ethanamine;2-(1-Aminoethyl)triphenylphosphine

Chemical Property of (S)-1-[2-(Diphenylphosphino)phenyl]ethylamine, min. 97%

Chemical Property:

• Melting Point: 76-81℃
• Boiling Point: 425.8±28.0 °C(Predicted)
• PKA: 8.73±0.10(Predicted)
• PSA: 39.61000
• LogP: 4.16480
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Sensitive.: Air Sensitive

Purity/Quality:

99% ^*data from raw suppliers

(S)-1-[2-(Diphenylphosphino)phenyl]ethylamine, min. 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of (S)-1-[2-(Diphenylphosphino)phenyl]ethylamine, min. 97%

There total 7 articles about (S)-1-[2-(Diphenylphosphino)phenyl]ethylamine, min. 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-<(S)-1-phenylethyl>(trimethylsilyl)amine (121443-77-4) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → (S)-1-(2-(diphenylphosphino)phenyl)ethanamine (913196-43-7)

Guidance literature:

N-<(S)-1-phenylethyl>(trimethylsilyl)amine; With n-butyllithium; In diethyl ether; hexane; at -35 - 20 ℃;

chloro-diphenylphosphine; In diethyl ether; hexane; at -35 - 20 ℃; for 7h;

DOI:10.1021/ol0617749

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → (S)-1-(2-(diphenylphosphino)phenyl)ethanamine (913196-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; hexane / 1 h / -35 °C

2.1: n-BuLi / diethyl ether; hexane / -35 - 20 °C

2.2: 1.22 g / diethyl ether; hexane / 7 h / -35 - 20 °C

With n-butyllithium; In diethyl ether; hexane;

DOI:10.1021/ol0617749

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → (S)-1-(2-(diphenylphosphino)phenyl)ethanamine (913196-43-7)

Guidance literature:

(S)-1-phenyl-ethylamine; With n-butyllithium; chloro-trimethyl-silane; In diethyl ether; at 0 ℃; Inert atmosphere;

chloro-diphenylphosphine; With n-butyllithium; In diethyl ether; at -30 ℃; Inert atmosphere;

DOI:10.1016/j.tetasy.2010.03.008

upstream raw materials:

N-<(S)-1-phenylethyl>(trimethylsilyl)amine

chloro-diphenylphosphine

(S)-1-phenyl-ethylamine

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

N-[bis(4-trifluoromethylphenyl)phosphino]-(S)-1-[2-(diphenylphosphino)phenyl]ethylamine

N-[bis(4-methylphenyl)phosphino]-(S)-1-[2-(diphenylphosphino)phenyl]ethylamine

N-[bis(3,5-difluorophenyl)phosphino]-(S)-1-[2-(diphenylphosphino)phenyl]ethylamine

N-{bis[3,5-bis(trifluoromethyl)phenyl]phosphino}-(S)-1-[2-(diphenylphosphino)phenyl]ethylamine

Refernces

• 1、 -. "COPPER CATALYZED HALOGENATON AND REACTION PRODUCTS". . . Retrieved 2015/01/06.
• 2、 Zhou, Xiao-Mao,Huang, Jia-Di,Luo, Li-Bin,Zhang, Cheng-Lu,Zheng, Zhuo,Hu, Xiang-Ping. "Readily available chiral phosphine-aminophosphine ligands derived from 1-phenylethylamine for Rh-catalyzed enantioselective hydrogenations". scheme or table. p. 420 - 424. Retrieved 2010/07/02.