2-aMino-N-(2,2-difluoroethyl)acetaMide hydrochloride

Base Information

• Chemical Name: 2-aMino-N-(2,2-difluoroethyl)acetaMide hydrochloride
• CAS No.: 1414642-43-5
• Molecular Formula: C4H9ClF2N2O
• Molecular Weight: 174.578
• Mol file: 1414642-43-5.mol

Synonyms:2-aMino-N-(2,2-difluoroethyl)acetaMide hydrochloride;2-Amino-N-(2,2-difluoro-ethyl)-acetamide

Chemical Property of 2-aMino-N-(2,2-difluoroethyl)acetaMide hydrochloride

Chemical Property:

• PSA: 55.12000
• LogP: 1.21960

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-N-(2,2-difluoroethyl)acetamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-aMino-N-(2,2-difluoroethyl)acetaMide hydrochloride

There total 1 articles about 2-aMino-N-(2,2-difluoroethyl)acetaMide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(2,2-difluoro-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester (1414642-52-6) → 2-amino-N-(2,2-difluoro-ethyl)-acetamide hydrochloride (1414642-43-5)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; Cooling with ice;

Reference yield: 88.0%

3-[5-(3,5-dichloro-4-fluoro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylic acid (1414378-26-9) + 2-amino-N-(2,2-difluoro-ethyl)-acetamide hydrochloride (1414642-43-5) → 3-[5-(3,5-dichloro-4-fluoro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylic acid [(2,2-difluoro-ethylcarbamoyl)-methyl]-amide (1414642-56-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 20 ℃; for 1h;

upstream raw materials:

[(2,2-difluoro-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

Downstream raw materials:

3-[5-(3,5-dichloro-4-fluoro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylic acid [(2,2-difluoro-ethylcarbamoyl)-methyl]-amide

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