TERT-BUTYL 4-(BROMOMETHYL)THIAZOL-2-YLCARBAMATE

Base Information

• Chemical Name: TERT-BUTYL 4-(BROMOMETHYL)THIAZOL-2-YLCARBAMATE
• CAS No.: 1001419-35-7
• Molecular Formula: C13H20N2O2
• Molecular Weight: 293.18
• Hs Code.: 2934100090
• Mol file: 1001419-35-7.mol

Synonyms:tert-butyl 4-(bromomethyl)-1,3-thiazol-2-ylcarbamate;

Chemical Property of TERT-BUTYL 4-(BROMOMETHYL)THIAZOL-2-YLCARBAMATE

Chemical Property:

• PKA: 4.97±0.70(Predicted)
• PSA: 79.46000
• Density: 1.537±0.06 g/cm3(Predicted)
• LogP: 3.45800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl 4-(bromomethyl)-1,3-thiazol-2-ylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-(BROMOMETHYL)THIAZOL-2-YLCARBAMATE

There total 7 articles about TERT-BUTYL 4-(BROMOMETHYL)THIAZOL-2-YLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,3-dibromoroacetone (816-39-7) + tert-butyl carbamothioylcarbamate (268551-65-1) → tert-butyl (4-(bromomethyl)thiazol-2-yl)carbamate (1001419-35-7)

Guidance literature:

In acetone; at 20 ℃; for 24h; Product distribution / selectivity;

Reference yield: 71.0%

(4-hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester (494769-44-7) → tert-butyl (4-(bromomethyl)thiazol-2-yl)carbamate (1001419-35-7)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at -78 ℃; for 0.25h; Inert atmosphere;

Reference yield:

C10H16N2O5S2 (1337606-64-0) → tert-butyl (4-(bromomethyl)thiazol-2-yl)carbamate (1001419-35-7)

Guidance literature:

With lithium bromide; In dichloromethane; acetone; at 20 ℃; for 1h; Product distribution / selectivity;

upstream raw materials:

C₁₀H₁₆N₂O₅S₂

1,3-dibromoroacetone

tert-butyl carbamothioylcarbamate

di-tert-butyl dicarbonate

Refernces

• 1、 -. "GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME". Page/Page column 32. . Retrieved 2018/02/28.
• 2、 -. "THIOBENZOIMIDAZOLE AS FUNGICIDES". Page/Page column 66. . Retrieved 2018/08/03.