4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl acetate

Base Information

• Chemical Name: 4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl acetate
• CAS No.: 905306-07-2
• Molecular Formula: C₁₉H₁₅N₃O₃
• Molecular Weight: 333.346
• Mol file: 905306-07-2.mol

Synonyms:4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl acetate

Chemical Property of 4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl acetate

There total 12 articles about 4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.9%

3-acetylenephenylamine (54060-30-9) + 6-acetoxy-4-chloro-7-methoxyquinazoline (230955-75-6) → 4-[(3-acetylenephenyl)amino]-7-methoxyquinazolin-6-yl acetate (905306-07-2)

Guidance literature:

In isopropyl alcohol; at 83 ℃;

Reference yield:

3H-6,7-dimethoxyquinazolin-4-one (13794-72-4) → 4-[(3-acetylenephenyl)amino]-7-methoxyquinazolin-6-yl acetate (905306-07-2)

Guidance literature:

Multi-step reaction with 4 steps

1: methanesulfonic acid; L-methionine / 120 °C

2: pyridine; dmap / 100 °C

3: trichlorophosphate / toluene / Reflux

4: pyridine / isopropyl alcohol / Reflux

With pyridine; dmap; methanesulfonic acid; L-methionine; trichlorophosphate; In isopropyl alcohol; toluene;

DOI:10.1016/j.bmcl.2012.05.069

Reference yield:

ethyl 2-nitro-4,5-dimethoxybenzoate (100905-33-7) → 4-[(3-acetylenephenyl)amino]-7-methoxyquinazolin-6-yl acetate (905306-07-2)

Guidance literature:

Multi-step reaction with 6 steps

1: palladium on activated charcoal; hydrogen

2: 160 - 170 °C

3: methanesulfonic acid; L-methionine / 120 °C

4: pyridine; dmap / 100 °C

5: trichlorophosphate / toluene / Reflux

6: pyridine / isopropyl alcohol / Reflux

With pyridine; dmap; methanesulfonic acid; L-methionine; palladium on activated charcoal; hydrogen; trichlorophosphate; In isopropyl alcohol; toluene;

DOI:10.1016/j.bmcl.2012.05.069

upstream raw materials:

2-carboethoxy-4,5-dimethoxyaniline

ethyl 2-nitro-4,5-dimethoxybenzoate

3-acetylenephenylamine

6-acetoxy-4-chloro-7-methoxyquinazoline

Downstream raw materials:

4-[(3-acetylenephenyl)amino]-7-methoxyquinazolin-6-ol

C₁₉H₁₆FN₃O₂

tert-butyl 5-(3-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

N-(3-ethynylphenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine