14-Methyl-5α-cholest-8-en-3β-ol

Base Information

• Chemical Name: 14-Methyl-5α-cholest-8-en-3β-ol
• CAS No.: 6062-47-1
• Molecular Formula: C28H48O
• Molecular Weight: 400.68
• Mol file: 6062-47-1.mol

Synonyms:14-Methyl-5α-cholest-8-en-3β-ol

Chemical Property of 14-Methyl-5α-cholest-8-en-3β-ol

Chemical Property:

• PSA: 20.23000
• LogP: 7.92290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 14-Methyl-5α-cholest-8-en-3β-ol

There total 5 articles about 14-Methyl-5α-cholest-8-en-3β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-Dimethyl-propionic acid (3S,5S,8R,9S,10S,13R,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (130257-76-0) → 14α-Methyl-5α-methyl-5α-cholest-8-en-3β-ol (6062-47-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / m-chloroperbenzoic acid

2: 75 percent / boron trifluoride etherate / benzene / 1 h / Ambient temperature

3: 73 percent / pyridinium chlorochromate / CH₂Cl₂

4: 73 percent / potassium tert-butoxide / 2-methyl-propan-2-ol

5: 1.) 80percent hydrazine hydrate, 2.) KOH / 1.) diethylene glycol, 160 deg C, 2.) 200 deg C

With potassium hydroxide; boron trifluoride diethyl etherate; potassium tert-butylate; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In dichloromethane; tert-butyl alcohol; benzene;

DOI:10.1248/cpb.38.1796

Reference yield:

14α,15α-Epoxy-5α-cholestan-3β-ol trimethylacetate (130257-74-8) → 14α-Methyl-5α-methyl-5α-cholest-8-en-3β-ol (6062-47-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / boron trifluoride etherate / benzene / 1 h / Ambient temperature

2: 73 percent / pyridinium chlorochromate / CH₂Cl₂

3: 73 percent / potassium tert-butoxide / 2-methyl-propan-2-ol

4: 1.) 80percent hydrazine hydrate, 2.) KOH / 1.) diethylene glycol, 160 deg C, 2.) 200 deg C

With potassium hydroxide; boron trifluoride diethyl etherate; potassium tert-butylate; hydrazine hydrate; pyridinium chlorochromate; In dichloromethane; tert-butyl alcohol; benzene;

DOI:10.1248/cpb.38.1796

Reference yield:

2,2-Dimethyl-propionic acid (3S,5S,10S,13R,14S,15S,17R)-17-((R)-1,5-dimethyl-hexyl)-15-hydroxy-10,13-dimethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (130257-75-9) → 14α-Methyl-5α-methyl-5α-cholest-8-en-3β-ol (6062-47-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / pyridinium chlorochromate / CH₂Cl₂

2: 73 percent / potassium tert-butoxide / 2-methyl-propan-2-ol

3: 1.) 80percent hydrazine hydrate, 2.) KOH / 1.) diethylene glycol, 160 deg C, 2.) 200 deg C

With potassium hydroxide; potassium tert-butylate; hydrazine hydrate; pyridinium chlorochromate; In dichloromethane; tert-butyl alcohol;

DOI:10.1248/cpb.38.1796

upstream raw materials:

2,2-Dimethyl-propionic acid (3S,5S,10S,13R,14R,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13,14-trimethyl-15-oxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

2,2-Dimethyl-propionic acid (3S,5S,8R,9S,10S,13R,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

14α,15α-Epoxy-5α-cholestan-3β-ol trimethylacetate

2,2-Dimethyl-propionic acid (3S,5S,10S,13R,14S,15S,17R)-17-((R)-1,5-dimethyl-hexyl)-15-hydroxy-10,13-dimethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Refernces