Tert-butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate
CAS No.:203520-03-0
Molecular Formula:C15H27N3O3
Molecular Weight:297.39
Hs Code.:2933599090
European Community (EC) Number:840-329-4
DSSTox Substance ID:DTXSID50445189
Wikidata:Q82263540
Mol file:203520-03-0.mol

Synonyms:203520-03-0;Tert-butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate;tert-butyl 4-[(piperidin-4-yl)carbonyl]piperazine-1-carboxylate;4-(Piperidine-4-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester;SCHEMBL1497328;DTXSID50445189;HUBWQZRKRPUKNT-UHFFFAOYSA-N;MFCD06808758;AKOS026730424;AM805050;BS-27715;4-(4-Piperidinylcarbonyl)-1-Boc-piperazine;CS-0038085;FT-0746972;EN300-89964;W15156;1-(tert-butoxycarbonyl)-4-(-4-piperidylcarbonyl)piperazine;1-(tert-butoxycarbonyl)-4-(piperidin-4-ylcarbonyl) piperazine;1-(tert-butoxycarbonyl)-4-(piperidin-4-ylcarbonyl)piperazine;t-Butyl 4-[(piperidin-4-yl)carbonyl]piperazine-1-carboxylate;4-(Piperidine-4-carbonyl)-piperazine-1-carboxylicacidtert-butylester;4-(piperidine-4-carbonyl)piperazine-1-carboxylic acid tert-butyl ester

Suppliers and Price of Tert-butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-(piperidine-4-carbonyl)piperazine-1-carboxylate 95+%
1g
$ 446.00

Crysdot
tert-Butyl4-(piperidine-4-carbonyl)piperazine-1-carboxylate 95+%
5g
$ 1340.00

ChemScene
tert-Butyl4-(piperidine-4-carbonyl)piperazine-1-carboxylate
1g
$ 530.00

AK Scientific
Tert-butyl4-(piperidine-4-carbonyl)piperazine-1-carboxylate
1g
$ 855.00

Acrotein
4-(4-Piperidinylcarbonyl)-1-Boc-piperazine 97%
0.5g
$ 183.30

Total 10 raw suppliers

Chemical Property of Tert-butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate

Chemical Property:

PSA：61.88000
LogP:1.26990
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:297.20524173
Heavy Atom Count:21
Complexity:378

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(piperidine-4-carbonyl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCN(CC1)C(=O)C2CCNCC2
Uses 4-(Piperidine-4-carbonyl)-piperazine-1-carboxylicacidtert-butylester is an intermediate; used in preparation of pyrrolopyrimidinylphenylbenzamides as BTK inhibitors.

Technology Process of Tert-butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate

There total 5 articles about Tert-butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 203520-02-9
1-(tert-butoxycarbonyl)-4-[1-benzyloxycarbonylpiperidin-4-ylcarbonyl]piperazine

: 203520-03-0
1-(tert-butoxycarbonyl)-4-(piperidin-4-ylcarbonyl)-piperazine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 18h;
DOI:10.1021/jm000139k

Reference yield:

: 10314-98-4
1-benzyloxycarbonylpiperidine-4-carboxylic acid

: 203520-03-0
1-(tert-butoxycarbonyl)-4-(piperidin-4-ylcarbonyl)-piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / EDAC; HOBt / dimethylformamide / 18 h

2: 71 percent / H₂ / 5 percent Pd/C / ethanol / 18 h

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm000139k

Reference yield:

: 498-94-2
isonipecotic acid

: 203520-03-0
1-(tert-butoxycarbonyl)-4-(piperidin-4-ylcarbonyl)-piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 44 percent / Na₂CO₃ / H₂O / 18 h

2: 76 percent / EDAC; HOBt / dimethylformamide / 18 h

3: 71 percent / H₂ / 5 percent Pd/C / ethanol / 18 h

With hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000139k