4-Oxazolecarboxylic acid, 4-(4-fluorophenyl)-4,5-dihydro-2-methyl-5-oxo-, ethyl ester

Base Information

Chemical Name:4-Oxazolecarboxylic acid, 4-(4-fluorophenyl)-4,5-dihydro-2-methyl-5-oxo-, ethyl ester
CAS No.:162247-71-4
Molecular Formula:C₁₃H₁₂FNO₄
Molecular Weight:265.241
Hs Code.:
Mol file:162247-71-4.mol

Synonyms:4-Oxazolecarboxylic acid, 4-(4-fluorophenyl)-4,5-dihydro-2-methyl-5-oxo-, ethyl ester

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Chemical Property of 4-Oxazolecarboxylic acid, 4-(4-fluorophenyl)-4,5-dihydro-2-methyl-5-oxo-, ethyl ester

Chemical Property:

Boiling Point:338.2±52.0 °C(Predicted)
PKA:0.88±0.40(Predicted)
PSA：64.96000
Density:1.30±0.1 g/cm3(Predicted)
LogP:0.99490

Purity/Quality:

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Technology Process of 4-Oxazolecarboxylic acid, 4-(4-fluorophenyl)-4,5-dihydro-2-methyl-5-oxo-, ethyl ester

There total 3 articles about 4-Oxazolecarboxylic acid, 4-(4-fluorophenyl)-4,5-dihydro-2-methyl-5-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54681-67-3,187868-53-7
2-acetamido-3-ethoxy-3-oxopropanoic acid

: 162247-71-4
4-(4-Fluoro-phenyl)-2-methyl-5-oxo-4,5-dihydro-oxazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 0.25 h / Ambient temperature

2: H₂O / diethyl ether / 1 h / Ambient temperature

3: 1.) Pb(OAc)4, Hg(OAc)2, 2.) pyridine / 1.) CHCl₃, 40 deg C, 1 h, 2.) 40 deg C, 1 h

With pyridine; lead(IV) acetate; mercury(II) diacetate; water; In diethyl ether;

Reference yield:

: 2-Methyl-5-(2,2,2-trifluoro-acetoxy)-oxazole-4-carboxylic acid ethyl ester

: 162247-71-4
4-(4-Fluoro-phenyl)-2-methyl-5-oxo-4,5-dihydro-oxazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂O / diethyl ether / 1 h / Ambient temperature

2: 1.) Pb(OAc)4, Hg(OAc)2, 2.) pyridine / 1.) CHCl₃, 40 deg C, 1 h, 2.) 40 deg C, 1 h

With pyridine; lead(IV) acetate; mercury(II) diacetate; water; In diethyl ether;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 162247-62-3
4-Ethoxycarbonyl-2-methyl-4,5-dihydro-1,3-oxazol-5-one

: 162247-71-4
4-(4-Fluoro-phenyl)-2-methyl-5-oxo-4,5-dihydro-oxazole-4-carboxylic acid ethyl ester

Guidance literature:: With pyridine; lead(IV) acetate; mercury(II) diacetate; Multistep reaction; 1.) CHCl₃, 40 deg C, 1 h, 2.) 40 deg C, 1 h;