20R 23S 24S-DINOSTERANE

Base Information

Chemical Name:20R 23S 24S-DINOSTERANE
CAS No.:146276-36-0
Molecular Formula:C₃₀H₅₄
Molecular Weight:414.759
Hs Code.:
Mol file:146276-36-0.mol

Synonyms:20R 23S 24S-DINOSTERANE;ALPHA, ALPHA, ALPHA 20R 23S 24S 4A,23,24-TRIMETHYLCHOLESTANE

Suppliers and Price of 20R 23S 24S-DINOSTERANE

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 20R 23S 24S-DINOSTERANE

Chemical Property:

Melting Point:161.5 - 162.5 °C
PSA：0.00000
LogP:9.23580

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 20R 23S 24S-DINOSTERANE

There total 33 articles about 20R 23S 24S-DINOSTERANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 148459-79-4
(20R,23S,24S)-5α-dinosteran-29-ol mesylate

: 146276-36-0,133908-07-3
(20R,23S,24S)-5α-Dinosterane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 5h; Heating;
DOI:10.1021/jo00064a039

Reference yield:

: 145-13-1
Pregnenolone

: 146276-36-0,133908-07-3
(20R,23S,24S)-5α-Dinosterane

Guidance literature:: Multi-step reaction with 17 steps

1: 79 percent / p-toluenesulfonic acid monohyrate

2: 78 percent / 1-methyl-4-piperidone, Al(O-i-Pr)3 / toluene / Heating

3: 54 percent / NEt₃ / ethanol; H₂O / 72 h / Heating

4: 54 percent / lithium, liquid NH₃ / tetrahydrofuran / 5 h / -78 °C

5: 87 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / 25 °C

6: 78 percent / pyridine / CH₂Cl₂

7: 82 percent / (n-Bu)3SnH, 2,2'-azobisisobutyronitrile / benzene / 4 h / Heating

8: 86 percent / 1 M aq. HCl, acetic acid / H₂O; tetrahydrofuran / 2 h / 25 °C

9: 91 percent / benzene / 1) reflux, 4.5 h, 2) 25 deg C, 12 h

10: 1) borane-THF, 2) 3 M NaOH, 30percent H₂O₂ / 1) THF, 25 deg C, 1 h, 2) water, 53 - 54 deg C, 3.5 h

11: 96 percent / NEt₃

12: 85 percent / NaI / acetone

14: 96 percent / imidazole / dimethylformamide / 0.5 h / 60 °C

15: 1) H₂, 2) (n-Bu)4NF / 1) PtO₂ / 1) hexane, 25 deg C, 60 psi, 3 h, 2) THF, 25 deg C, 24 h

16: 99 percent / NEt₃

17: 93 percent / LiAlH₄ / tetrahydrofuran / 5 h / Heating

With pyridine; 1H-imidazole; 1-Methyl-4-piperidone; hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; borane-THF; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; ammonia; hydrogen; dihydrogen peroxide; tri-n-butyl-tin hydride; aluminum isopropoxide; lithium; toluene-4-sulfonic acid; acetic acid; triethylamine; sodium iodide; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; benzene;
DOI:10.1021/jo00064a039

Reference yield:

: 20817-72-5,55722-32-2,83603-21-8
(22E)-stigmasta-4,22-dien-3-one

: 146276-36-0,133908-07-3
(20R,23S,24S)-5α-Dinosterane

Guidance literature:: Multi-step reaction with 12 steps

1: 62 percent / NEt₃ / ethanol; H₂O / 72 h / Heating

2: 82 percent / lithium, liquid NH₃ / tetrahydrofuran / -78 °C

3: pyridine / CH₂Cl₂

4: tri-n-butyltin hydride, 2,2'-azobisisobutyronitrile / benzene / Heating

6: 96 percent / NEt₃

7: 85 percent / NaI / acetone

9: 96 percent / imidazole / dimethylformamide / 0.5 h / 60 °C

10: 1) H₂, 2) (n-Bu)4NF / 1) PtO₂ / 1) hexane, 25 deg C, 60 psi, 3 h, 2) THF, 25 deg C, 24 h

11: 99 percent / NEt₃

12: 93 percent / LiAlH₄ / tetrahydrofuran / 5 h / Heating

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; ammonia; hydrogen; tri-n-butyl-tin hydride; lithium; triethylamine; sodium iodide; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo00064a039