CyclopropaneMethanaMine, α-(trifluoroMethyl)-, (αR)-

Base Information

• Chemical Name: CyclopropaneMethanaMine, α-(trifluoroMethyl)-, (αR)-
• CAS No.: 1131737-04-6
• Molecular Formula: C5H8F3N
• Molecular Weight: 139.12
• Mol file: 1131737-04-6.mol

Synonyms:CyclopropaneMethanaMine, α-(trifluoroMethyl)-, (αR)-;(alphaR)-alpha-(Trifluoromethyl)cyclopropanemethanamine

Chemical Property of CyclopropaneMethanaMine, α-(trifluoroMethyl)-, (αR)-

Chemical Property:

• Boiling Point: 125.8±35.0 °C(Predicted)
• PKA: 5.71±0.50(Predicted)
• PSA: 26.02000
• Density: 1.277±0.06 g/cm3(Predicted)
• LogP: 1.98630

Purity/Quality:

≥98% ^*data from raw suppliers

(1R)-1-Cyclopropyl-2,2,2-trifluoroethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CyclopropaneMethanaMine, α-(trifluoroMethyl)-, (αR)-

There total 1 articles about CyclopropaneMethanaMine, α-(trifluoroMethyl)-, (αR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-benzyl-1-cyclopropyl-2,2,2-trifluoroethan-1-amine → 1-cyclopropyl-2,2,2-trifluoroethan-1-amine (1131737-04-6)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 16h;

Reference yield:

C5H8F3N (1131737-04-6) → C29H29F3N6O4S

Guidance literature:

Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -78 - 20 °C

2.1: tin(ll) chloride / ethanol / 4 h / Reflux

3.1: potassium carbonate / acetone / 16 h / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C

5.1: triethylamine / tetrahydrofuran

5.2: 18 h / 20 °C

6.1: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 18 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; oxalyl dichloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetone; 6.1: |Suzuki Coupling;

DOI:10.1021/acsmedchemlett.0c00575

Refernces

• 1、 -. "PYRROLO[1,2-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS". Paragraph 00259. . Retrieved 2017/11/04.