4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol

Base Information

Chemical Name:4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol
CAS No.:475086-75-0
Molecular Formula:C23H27N3O
Molecular Weight:361.487
Hs Code.:
European Community (EC) Number:813-799-3
Mol file:475086-75-0.mol

Synonyms:475086-75-0;4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol;Selexipag intermediate;4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-Butanol;4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butan-1-ol;4-[(5,6-diphenylpyrazin-2-yl)-propan-2-ylamino]butan-1-ol;4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]-1-butanol;1-Butanol, 4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]-;4-[(5,6-Diphenylpyrazinyl)(1-methylethyl)amino]-1-butanol;4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)-1-butanol;4-[(5,6-DIPHENYLPYRAZIN-2-YL)(ISOPROPYL)AMINO]BUTAN-1-OL;SCHEMBL2132049;C23H27N3O;PKBSUZWFQXNCSI-UHFFFAOYSA-N;AMY25406;BCP15533;CS-M3070;AKOS030524827;AS-57814;DB-123206;4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]-1-butanol

Suppliers and Price of 4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol 97%
5g
$ 470.00

Crysdot
4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol 97%
1g
$ 200.00

ChemScene
1-Butanol,4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]-
1g
$ 100.00

Chemenu
4-[(5,6-Diphenylpyrazinyl)(1-methylethyl)amino]-1-butanol 95%+
10g
$ 974.00

Chemenu
4-[(5,6-Diphenylpyrazinyl)(1-methylethyl)amino]-1-butanol 95%+
5g
$ 545.00

Chemenu
4-[(5,6-Diphenylpyrazinyl)(1-methylethyl)amino]-1-butanol 95%+
1g
$ 182.00

Chemenu
4-[(5,6-Diphenylpyrazinyl)(1-methylethyl)amino]-1-butanol 95%+
250mg
$ 92.00

Chemenu
4-[(5,6-Diphenylpyrazinyl)(1-methylethyl)amino]-1-butanol 95%+
100mg
$ 68.00

Ambeed
4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol 98%
250mg
$ 48.00

Ambeed
4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol 98%
1g
$ 112.00

Total 76 raw suppliers

Chemical Property of 4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol

Chemical Property:

Boiling Point:514.4±50.0 °C(Predicted)
PKA:15.05±0.10(Predicted)
PSA：49.25000
Density:1.112±0.06 g/cm3(Predicted)
LogP:4.79790
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Chloroform (Slightly), DMSO (Slightly)
XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:361.215412493
Heavy Atom Count:27
Complexity:404

Purity/Quality:

HPLC>99%, max single impurity NMT 0.3% ^*data from raw suppliers

4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)N(CCCCO)C1=CN=C(C(=N1)C2=CC=CC=C2)C3=CC=CC=C3
Uses 4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-butanol is a diphenylpyrazine derivative which belongs to a class of prostacyclin receptor agonists. It is an impurity of Selexipag (S253150) that is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.

Technology Process of 4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol

There total 31 articles about 4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 41270-66-0
2-chloro-5,6-diphenylpyrazine

: 42042-71-7
4-hydroxy-N-isopropylbutan-1-amine

: 475086-75-0
4-[N-(5,6-diphenylpyrazine-2-yl)-N-isopropylamino]-1-butanol

Guidance literature:: With tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In 1,4-dioxane; at 120 ℃; for 1.8h; Reagent/catalyst; Temperature; Solvent;