(E)-methyl 3-(pyrimidin-5-yl)acrylate

Base Information

Chemical Name:(E)-methyl 3-(pyrimidin-5-yl)acrylate
CAS No.:866621-24-1
Molecular Formula:C₈H₈N₂O₂
Molecular Weight:164.164
Hs Code.:2933599090
European Community (EC) Number:856-605-2
Mol file:866621-24-1.mol

Synonyms:(E)-methyl 3-(pyrimidin-5-yl)acrylate;866621-24-1;224776-14-1;Methyl 3-(pyrimidin-5-yl)acrylate;METHYL 3-PYRIMIDIN-5-YL-ACRYLATE;methyl 3-(pyrimidin-5-yl)prop-2-enoate;METHYL (2E)-3-(PYRIMIDIN-5-YL)PROP-2-ENOATE;methyl (E)-3-pyrimidin-5-ylprop-2-enoate;MFCD08166596;methyl 3-pyrimidin-5-ylprop-2-enoate;SCHEMBL7005278;XGHMTMQOSKKDGC-NSCUHMNNSA-N;AMY24024;AKOS006287648;AKOS023502127;(E)-methyl3-(pyrimidin-5-yl)acrylate;AS-30980;DB-344832;CS-0246744;CS-0369110;Methyl (2E)-3-(5-pyrimidinyl)-2-propenoate;EN300-206308;EN300-342563;A816219;Z2177030874

Suppliers and Price of (E)-methyl 3-(pyrimidin-5-yl)acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(E)-methyl3-(pyrimidin-5-yl)acrylate
500mg
$ 310.00

SynQuest Laboratories
Methyl 3-(pyrimidin-5-yl)acrylate 95%
10 g
$ 990.00

Alichem
(E)-Methyl3-(pyrimidin-5-yl)acrylate
5g
$ 877.68

Alichem
(E)-Methyl3-(pyrimidin-5-yl)acrylate
1g
$ 300.84

Total 5 raw suppliers

Chemical Property of (E)-methyl 3-(pyrimidin-5-yl)acrylate

Chemical Property:

Vapor Pressure:0.0021mmHg at 25°C
Boiling Point:290.2°C at 760 mmHg
PKA:1.70±0.10(Predicted)
Flash Point:129.3°C
PSA：52.08000
Density:1.199g/cm³
LogP:0.66280
XLogP3:0.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:164.058577502
Heavy Atom Count:12
Complexity:174

Purity/Quality:

98%,99%, ^*data from raw suppliers

(E)-methyl3-(pyrimidin-5-yl)acrylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C=CC1=CN=CN=C1
Isomeric SMILES:COC(=O)/C=C/C1=CN=CN=C1

Technology Process of (E)-methyl 3-(pyrimidin-5-yl)acrylate

There total 1 articles about (E)-methyl 3-(pyrimidin-5-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 4595-59-9
5-bromopyrimidine

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 866621-24-1,224776-14-1
(E)-methyl 3-(5-pyrimidinyl)acrylate

Guidance literature:: With palladium diacetate; N-ethyl-N,N-diisopropylamine; phosphorous acid trimethyl ester; In N,N-dimethyl-formamide; at 110 ℃; for 1h; Inert atmosphere;
DOI:10.1021/op050106k

Reference yield:

: 866621-24-1,224776-14-1
(E)-methyl 3-(5-pyrimidinyl)acrylate

: 1380426-91-4
2-[[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl](methyl)amino]-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium on activated charcoal / methanol / 50 °C

2.1: potassium tert-butylate / tetrahydrofuran / 4 h / Cooling with ice; Inert atmosphere

2.2: pH 5

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 3 h / 200 °C / Microwave irradiation

With potassium tert-butylate; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;

Reference yield:

: 866621-24-1,224776-14-1
(E)-methyl 3-(5-pyrimidinyl)acrylate

: 1380426-75-4
2-[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium on activated charcoal / methanol / 50 °C

2.1: potassium tert-butylate / tetrahydrofuran / 4 h / Cooling with ice; Inert atmosphere

2.2: pH 5

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C / Microwave irradiation

With potassium tert-butylate; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;