tert-butyl 3'-amino-1'h-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'h)-carboxylate

Base Information

• Chemical Name: tert-butyl 3'-amino-1'h-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'h)-carboxylate
• CAS No.: 1246652-29-8
• Molecular Formula: C₁₃H₂₀N₄O₂
• Molecular Weight: 264.327
• Hs Code.: 2933990090
• Mol file: 1246652-29-8.mol

Synonyms:tert-butyl 3'-amino-1'h-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'h)-carboxylate

Chemical Property of tert-butyl 3'-amino-1'h-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'h)-carboxylate

Chemical Property:

• PSA: 84.97000
• LogP: 1.98980

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl3'-amino-1',4'-dihydro-5'H-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 3'-amino-1'h-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'h)-carboxylate

There total 4 articles about tert-butyl 3'-amino-1'h-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'h)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.3%

tert-butyl 7-cyano-8-hydroxy-5-azaspiro[3.4]oct-7-ene-5-carboxylate → tert-butyl 3'-amino-1'H-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'H)-carboxylate (1246652-29-8)

Guidance literature:

With acetic acid; hydrazine; In ethanol; at 85 ℃; for 3h;

DOI:10.1016/j.bmc.2018.03.021

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 3'-amino-1'H-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'H)-carboxylate (1246652-29-8)

Guidance literature:

Multi-step reaction with 4 steps

1: tetramethyl ammoniumhydroxide / acetonitrile / 16 h / 50 °C

2: potassium hydrogencarbonate / N,N-dimethyl-formamide / 16 h / 40 °C

3: potassium tert-butylate / toluene / 16 h / 0 - 25 °C

4: hydrazine; acetic acid / ethanol / 3 h / 85 °C

With potassium tert-butylate; tetramethyl ammoniumhydroxide; potassium hydrogencarbonate; acetic acid; hydrazine; In ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1016/j.bmc.2018.03.021

Reference yield:

1-((tert-butoxycarbonyl)(2-cyanoethyl)amino)cyclobutanecarboxylic acid → tert-butyl 3'-amino-1'H-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'H)-carboxylate (1246652-29-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 16 h / 40 °C

2: potassium tert-butylate / toluene / 16 h / 0 - 25 °C

3: hydrazine; acetic acid / ethanol / 3 h / 85 °C

With potassium tert-butylate; potassium hydrogencarbonate; acetic acid; hydrazine; In ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmc.2018.03.021

upstream raw materials:

di-tert-butyl dicarbonate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1246652-29-8 tert-butyl 3'-amino-1'h-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'h)-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send