1-(3-AZETIDINYL)-4-(METHYLSULFONYL)-PIPERAZINE

Base Information

• Chemical Name: 1-(3-AZETIDINYL)-4-(METHYLSULFONYL)-PIPERAZINE
• CAS No.: 178311-72-3
• Molecular Formula: C8H17N3O2S
• Molecular Weight: 219.3
• Mol file: 178311-72-3.mol

Synonyms:1-(3-AZETIDINYL)-4-(METHYLSULFONYL)-PIPERAZINE;1-(3-Azetidinyl)-4-(mesyl)piperazine 2HCl

Chemical Property of 1-(3-AZETIDINYL)-4-(METHYLSULFONYL)-PIPERAZINE

Chemical Property:

• PSA: 61.03000
• LogP: -0.17920

Purity/Quality:

95%-98% ^*data from raw suppliers

1-(3-AZETIDINYL)-4-(METHYLSULFONYL)-PIPERAZINE 95.00% ^*data from reagent suppliers

Safty Information:

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Technology Process of 1-(3-AZETIDINYL)-4-(METHYLSULFONYL)-PIPERAZINE

There total 1 articles about 1-(3-AZETIDINYL)-4-(METHYLSULFONYL)-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-Diphenylmethyl-3-(4-methanesulphonylpiperazin-1-yl)azetidine (178312-05-5) + 3-(4-Methanesulphonylpiperazine)azetidine (178311-72-3)

Guidance literature:

Reference yield: 47.0%

3-(4-Methanesulphonylpiperazine)azetidine (178311-72-3) + [(S)-1-Cyclopropylmethyl-3-(3,4-dichloro-phenyl)-6-oxo-piperidin-3-yl]-acetaldehyde (178312-07-7) → (5S)-1-(cyclopropylmethyl)-5-(3,4-dichlorophenyl)-5-(2-{3[4-(methylsulfonyl)-1-piperazinyl]-1-azetidinyl}ethyl)-2-piperidone

Guidance literature:

3-(4-Methanesulphonylpiperazine)azetidine; [(S)-1-Cyclopropylmethyl-3-(3,4-dichloro-phenyl)-6-oxo-piperidin-3-yl]-acetaldehyde; With triethylamine; In tetrahydrofuran; for 1h;

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃; for 16h; Further stages.;

DOI:10.1021/jm0209331

Reference yield: 8.0%

3-(4-Methanesulphonylpiperazine)azetidine (178311-72-3) + 1-benzyl-5-(3,4-dichlorophenyl)-5-formylmethyl-2-piperidone (178311-27-8) → 1-benzyl-5-(3,4-dichloro-phenyl)-5-{2-[3-(4-methanesulfonyl-piperazin-1-yl)-azetidin-1-yl]-ethyl}-piperidin-2-one

Guidance literature:

3-(4-Methanesulphonylpiperazine)azetidine; 1-benzyl-5-(3,4-dichlorophenyl)-5-formylmethyl-2-piperidone; With triethylamine; In tetrahydrofuran; for 1h;

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃; for 16h; Further stages.;

DOI:10.1021/jm0209331

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