(R)-MG132

Base Information

Chemical Name:(R)-MG132
CAS No.:1211877-36-9
Molecular Formula:C26H41N3O5
Molecular Weight:475.629
Hs Code.:
Mol file:1211877-36-9.mol

Synonyms:(R)-MG132;Cbz-L-leu-D-leu-L-leu-H;N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide

Suppliers and Price of (R)-MG132

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-MG-132
2.5mg
$ 85.00

Tocris
(R)-MG132 ≥98%(HPLC)
10
$ 310.00

Sigma-Aldrich
MG-132(R) ≥95% (HPLC)
5mg
$ 378.00

ChemScene
(R)-MG-132 ≥98.0%
50mg
$ 980.00

ChemScene
(R)-MG-132 ≥98.0%
10mg
$ 320.00

ChemScene
(R)-MG-132 ≥98.0%
5mg
$ 180.00

Cayman Chemical
(R)-MG132 ≥98%
5mg
$ 166.00

Cayman Chemical
(R)-MG132 ≥98%
10mg
$ 280.00

Cayman Chemical
(R)-MG132 ≥98%
1mg
$ 35.00

Cayman Chemical
(R)-MG132 ≥98%
25mg
$ 656.00

Total 43 raw suppliers

Chemical Property of (R)-MG132

Chemical Property:

PSA：113.60000
LogP:4.76090
Storage Temp.:-20°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-MG-132 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or mis-folded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression. (R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC50s = 0.22 versus 0.89 μM (ChTL); 34.4 versus 104.43 μM (TL); 2.95 versus 5.70 μM (PGPH), respectively).
Uses (R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor. (R)-MG-132 is a potent, reversible and selective tripeptide aldehyde proteasome inhibitor.

Technology Process of (R)-MG132

There total 1 articles about (R)-MG132 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%