Octahydropyrazino[2,1-c][1,4]oxazine

Base Information

• Chemical Name: Octahydropyrazino[2,1-c][1,4]oxazine
• CAS No.: 141108-65-8
• Molecular Formula: C7H14N2O
• Molecular Weight: 142.201
• European Community (EC) Number: 818-972-7,896-996-7
• Mol file: 141108-65-8.mol

Synonyms:octahydropyrazino[2,1-c][1,4]oxazine;141108-65-8;octahydropiperazino[2,1-c]morpholine;1,3,4,6,7,8,9,9a-octahydropyrazino[2,1-c][1,4]oxazine;MFCD18830120;MFCD22581549;(9aR)-octahydropiperazino[2,1-c]morpholine;(s)-octahydro-pyrazino[2,1-c][1,4]oxazine;Pyrazino[2,1-c][1,4]oxazine, octahydro-;SCHEMBL337751;ZWNWCROZSHWHSF-UHFFFAOYSA-N;MFCD16987802;AKOS006357135;SB11252;SB11254;SB21816;octahydro-pyrazino[2,1-c][1,4]oxazine;AM806423;BS-13348;SY275672;SY275674;CS-0183395;(RS)-Octahydropyrazino[2,1-c][1,4]oxazine;EN300-128167;A934368;F2147-1722

Chemical Property of Octahydropyrazino[2,1-c][1,4]oxazine

Chemical Property:

• PSA: 24.50000
• LogP: -0.44290
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 142.110613074
• Heavy Atom Count: 10
• Complexity: 118

Purity/Quality:

98% ^*data from raw suppliers

Octahydropyrazino[2,1-C][1,4]oxazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN2CCOCC2CN1

Technology Process of Octahydropyrazino[2,1-c][1,4]oxazine

There total 8 articles about Octahydropyrazino[2,1-c][1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

hexahydropyrazino[2,1-c][1,4]oxazin-4-one (908066-25-1) → octahydropyrazino[2,1-c][1,4]oxazine (141108-65-8)

Guidance literature:

hexahydropyrazino[2,1-c][1,4]oxazin-4-one; With borane-THF; In tetrahydrofuran; at 60 ℃; for 24h;

With methanol; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

hexahydropyrazino[2,1-c][1,4]oxazin-9(6H)-one (929047-10-9) → octahydropyrazino[2,1-c][1,4]oxazine (141108-65-8)

Guidance literature:

hexahydropyrazino[2,1-c][1,4]oxazin-9(6H)-one; With borane-THF; In tetrahydrofuran; at 90 ℃; for 28h;

With methanol;

Reference yield:

(9aR)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine (1126432-05-0) → octahydropyrazino[2,1-c][1,4]oxazine (141108-65-8)

Guidance literature:

palladium-carbon; In ethanol;

upstream raw materials:

(9aR)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine

hexahydropyrazino[2,1-c][1,4]oxazin-4-one

4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid

hexahydropyrazino[2,1-c][1,4]oxazin-9(6H)-one

Downstream raw materials:

2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-(hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-3-pyridinyl]-N,2-dimethylpropanamide

C₂₂H₂₄ClFN₄O₄

C₂₁H₂₂ClFN₄O₄

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