5-(TrifluoroMethyl)benzoxazole

Base Information

• Chemical Name: 5-(TrifluoroMethyl)benzoxazole
• CAS No.: 1267217-46-8
• Molecular Formula: C8H4F3NO
• Molecular Weight: 187.121
• Hs Code.: 2934999090
• Mol file: 1267217-46-8.mol

Synonyms:5-(TrifluoroMethyl)benzoxazole;5-(TrifluoroMethyl)benzo[d]oxazole;5-(Trifluoromethyl)-1,3-benzoxazole 95%;5-(Trifluoromethyl)-1,3-benzoxazole95%

Chemical Property of 5-(TrifluoroMethyl)benzoxazole

Chemical Property:

• PSA: 26.03000
• LogP: 2.84660
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-(Trifluoromethyl)benzoxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(TrifluoroMethyl)benzoxazole

There total 2 articles about 5-(TrifluoroMethyl)benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-amino-4-(trifluoromethyl)phenol (454-81-9) + orthoformic acid triethyl ester (122-51-0) → 5-(trifluoromethyl)benzo[d]oxazole (1267217-46-8)

Guidance literature:

at 130 ℃;

Reference yield: 40.0%

2-nitro-4-trifluoromethylphenol (400-99-7) + orthoformic acid triethyl ester (122-51-0) → 5-(trifluoromethyl)benzo[d]oxazole (1267217-46-8)

Guidance literature:

2-nitro-4-trifluoromethylphenol; With palladium on activated charcoal; hydrogen; In ethanol; at 0 - 20 ℃; Inert atmosphere;

orthoformic acid triethyl ester; With toluene-4-sulfonic acid; In ethanol; for 3h; Inert atmosphere; Reflux;

Reference yield: 91.0%

5-(trifluoromethyl)benzo[d]oxazole (1267217-46-8) + Benzoylformic acid (611-73-4) → C21H12F3NO2 (1602493-36-6)

Guidance literature:

With trifluoroacetic acid; In isopropyl alcohol; at 70 ℃; for 18h;

DOI:10.1039/c4ra01605j

upstream raw materials:

2-nitro-4-trifluoromethylphenol

orthoformic acid triethyl ester

2-amino-4-(trifluoromethyl)phenol

Downstream raw materials:

2-phenylthio-5-trifluoromethyl-1,3-benzoxazole

phenyl isopropyl ketone

2-phenyl-5-(trifluoromethyl)benzo[d]oxazole

C₂₁H₁₂F₃NO₂

Refernces

• 1、 -. "COMPOUND HAVING ZNF143 INHIBITORY ACTIVITY AND USE THEREOF". Paragraph 0108. . Retrieved 2016/10/27.