4-(2-(Dimethylamino)ethyl)-1,4-diazepan-5-one

Base Information

• Chemical Name: 4-(2-(Dimethylamino)ethyl)-1,4-diazepan-5-one
• CAS No.: 344779-07-3
• Molecular Formula: C9H19N3O
• Molecular Weight: 185
• DSSTox Substance ID: DTXSID40391803
• Wikidata: Q82189521
• Mol file: 344779-07-3.mol

Synonyms:4-(2-(Dimethylamino)ethyl)-1,4-diazepan-5-one;344779-07-3;4-[2-(dimethylamino)ethyl]-1,4-diazepan-5-one;4-2-(dimethylamino)ethyl-1,4-diazepan-5-one;4-(2-Dimethylamino-ethyl)-[1,4]diazepan-5-one;SCHEMBL2657327;DTXSID40391803;MFCD03160593;AKOS006277504;DS-5605;CS-0151277;FT-0763376;Y10617;A874962

Chemical Property of 4-(2-(Dimethylamino)ethyl)-1,4-diazepan-5-one

Chemical Property:

• PSA: 35.58000
• LogP: -0.36340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: -1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 185.152812238
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

97% ^*data from raw suppliers

4-(2-(Dimethylamino)ethyl)-1,4-diazepan-5-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCN1CCNCCC1=O

Technology Process of 4-(2-(Dimethylamino)ethyl)-1,4-diazepan-5-one

There total 2 articles about 4-(2-(Dimethylamino)ethyl)-1,4-diazepan-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

C16H23N3O3 → 4-(2-(dimethylamino)ethyl)-1,4-diazepan-5-one (344779-07-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2011.09.078

Reference yield:

benzyl 5-oxo-1,4-diazepane-1-carboxylate (18158-16-2) → 4-(2-(dimethylamino)ethyl)-1,4-diazepan-5-one (344779-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.09.078

Reference yield:

5-tert-butyl-2-(3-(2,3-dichlorophenyl)ureido)thiophene-3-carboxylic acid (890926-64-4) + 4-(2-(dimethylamino)ethyl)-1,4-diazepan-5-one (344779-07-3) → 1-(5-tert-butyl-3-(4-(2-dimethylaminoethyl)-5-oxo-1,4-diazepane-1-carbonyl)-thiophen-2-yl)-3-(2,3-dichlorophenyl)urea

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 27h;

DOI:10.1016/j.bmcl.2011.09.078

upstream raw materials:

benzyl 5-oxo-1,4-diazepane-1-carboxylate

Downstream raw materials:

4-(2-dimethylaminoethyl)-1-[3-(2-Fluorophenyl)-[1,2,3]triazolo[1,5-a]quinazolin-5-yl]-[1,4]diazepan-5-one

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