4-ETHYL-PIPERAZINE-1-CARBONYL CHLORIDE

Base Information

• Chemical Name: 4-ETHYL-PIPERAZINE-1-CARBONYL CHLORIDE
• CAS No.: 53788-12-8
• Molecular Formula: C7H13ClN2O
• Molecular Weight: 176.646
• Mol file: 53788-12-8.mol

Synonyms:4-ETHYL-PIPERAZINE-1-CARBONYL CHLORIDE

Chemical Property of 4-ETHYL-PIPERAZINE-1-CARBONYL CHLORIDE

Chemical Property:

• Boiling Point: 264.2±29.0 °C(Predicted)
• PKA: 7.10±0.10(Predicted)
• PSA: 23.55000
• Density: 1.159±0.06 g/cm3(Predicted)
• LogP: 0.85850

Purity/Quality:

99% ^*data from raw suppliers

4-ETHYL PIPERAZINE-1-CARBONYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ETHYL-PIPERAZINE-1-CARBONYL CHLORIDE

There total 3 articles about 4-ETHYL-PIPERAZINE-1-CARBONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-benzyl-4-ethylpiperazine (91904-12-0) + bis(trichloromethyl) carbonate (32315-10-9) → 4-ethyl-piperazine-1-carbonyl chloride (53788-12-8)

Guidance literature:

In dichloromethane; for 24h; Ambient temperature;

DOI:10.1080/00397919808005960

Reference yield:

4-ethylpiperazine (5308-25-8) + bis(trichloromethyl) carbonate (32315-10-9) → 4-ethyl-piperazine-1-carbonyl chloride (53788-12-8)

Guidance literature:

With N,N-dimethyl-formamide; In tetrachloromethane; for 6h; Reflux;

DOI:10.1111/cbdd.12727

Reference yield:

→ 4-ethyl-piperazine-1-carbonyl chloride (53788-12-8)

Guidance literature:

upstream raw materials:

1-benzyl-4-ethylpiperazine

bis(trichloromethyl) carbonate

4-ethylpiperazine

Refernces

• 1、 Shan, Wei-Guang,Wang, Han-Guang,Chen, Yan,Wu, Rui,Wen, Yan-Tao,Zhang, Li-Wen,Ying, You-Min,Wang, Jian-Wei,Zhan, Zha-Jun. "Synthesis of 3- and 29-substituted celastrol derivatives and structure-activity relationship studies of their cytotoxic activities". supporting information. p. 3450 - 3453. Retrieved 2017/07/07.
• 2、 Jorand-Lebrun, Catherine,Valognes, Delphine,Halazy, Serge. "Use of triphosgene for direct preparation of carbamoyl chlorides from tertiary benzylamines". . p. 1189 - 1195. Retrieved 2007/10/03.