6-Aminobenzo[b]thiophene 1,1-dioxide

Base Information

• Chemical Name: 6-Aminobenzo[b]thiophene 1,1-dioxide
• CAS No.: 1261609-83-9
• Molecular Formula: C8H6BrNO
• Molecular Weight: 212.046
• Hs Code.: 2926907090
• Mol file: 1261609-83-9.mol

Synonyms:2-Bromo-5-(hydroxymethyl)benzonitrile

Chemical Property of 6-Aminobenzo[b]thiophene 1,1-dioxide

Chemical Property:

• Boiling Point: 360.8±32.0 °C(Predicted)
• PKA: 13.80±0.10(Predicted)
• PSA: 44.02000
• Density: 1.67±0.1 g/cm3(Predicted)
• LogP: 1.81308
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-5-(hydroxymethyl)benzonitrile 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Aminobenzo[b]thiophene 1,1-dioxide

There total 2 articles about 6-Aminobenzo[b]thiophene 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 2-bromo-5-(hydroxymethyl)benzonitrile (1261609-83-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h;

Reference yield: 65.0%

2-bromo-5-formylbenzonitrile → 2-bromo-5-(hydroxymethyl)benzonitrile (1261609-83-9)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 20 ℃; Inert atmosphere; Cooling with ice;

Reference yield: 56.0%

2-bromo-5-(hydroxymethyl)benzonitrile (1261609-83-9) → 2-bromo-5-(chloromethyl)benzonitrile

Guidance literature:

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1.25h; Cooling with ice;

Refernces

• 1、 -. "N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS". Paragraph 00615; 00644. . Retrieved 2014/06/11.