7-O-(Triethylsilyl)-2'-O-tert-butyl(dimethyl)silyl 2-Debenzoyl Paclitaxel 2-Pentanoate

Base Information

Chemical Name:7-O-(Triethylsilyl)-2'-O-tert-butyl(dimethyl)silyl 2-Debenzoyl Paclitaxel 2-Pentanoate
CAS No.:1055033-93-6
Molecular Formula:C₅₇H₈₃NO₁₄Si₂
Molecular Weight:1062.46
Hs Code.:
DSSTox Substance ID:DTXSID80440945
Wikidata:Q82257453
Mol file:1055033-93-6.mol

Synonyms:1055033-93-6;[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-[tert-butyl(dimethyl)silyl]oxy-3-phenylpropanoyl]oxy-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-triethylsilyloxy-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] pentanoate;7-O-(Triethylsilyl)-2'-O-tert-butyl(dimethyl)silyl 2-Debenzoyl Paclitaxel 2-Pentanoate;DTXSID80440945;WRUFGKOUUYXVIA-XZLAFKNDSA-N;7-O-(Triethylsilyl)-2 inverted exclamation mark -O-tert-butyl(dimethyl)silyl 2-Debenzoyl Paclitaxel 2-Pentanoate

Suppliers and Price of 7-O-(Triethylsilyl)-2'-O-tert-butyl(dimethyl)silyl 2-Debenzoyl Paclitaxel 2-Pentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
7-O-(Triethylsilyl)-2??-O-tert-butyl(dimethyl)silyl2-DebenzoylPaclitaxel2-Pentanoate
100 mg
$ 2440.00

Total 2 raw suppliers

Chemical Property of 7-O-(Triethylsilyl)-2'-O-tert-butyl(dimethyl)silyl 2-Debenzoyl Paclitaxel 2-Pentanoate

Chemical Property:

PSA：202.78000
LogP:10.24590
Storage Temp.:-20°C Freezer
Solubility.:Chloroform, Dichloromethane, Ethyl Acetate, Methanol
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:24
Exact Mass:1061.53520939
Heavy Atom Count:74
Complexity:2100

Purity/Quality:

98% ^*data from raw suppliers

7-O-(Triethylsilyl)-2??-O-tert-butyl(dimethyl)silyl2-DebenzoylPaclitaxel2-Pentanoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC(=O)OC1C2C(C(CC3C2(CO3)OC(=O)C)O[Si](CC)(CC)CC)(C(=O)C(C4=C(C(CC1(C4(C)C)O)OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O[Si](C)(C)C(C)(C)C)C)OC(=O)C)C
Isomeric SMILES:CCCCC(=O)O[C@H]1[C@H]2[C@@]([C@H](C[C@@H]3[C@]2(CO3)OC(=O)C)O[Si](CC)(CC)CC)(C(=O)[C@@H](C4=C([C@H](C[C@@]1(C4(C)C)O)OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O[Si](C)(C)C(C)(C)C)C)OC(=O)C)C
Uses Paclitaxel (Taxol) analog.

Technology Process of 7-O-(Triethylsilyl)-2'-O-tert-butyl(dimethyl)silyl 2-Debenzoyl Paclitaxel 2-Pentanoate

There total 4 articles about 7-O-(Triethylsilyl)-2'-O-tert-butyl(dimethyl)silyl 2-Debenzoyl Paclitaxel 2-Pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33069-62-4
taxol

: 1055033-93-6
C₅₇H₈₃NO₁₄Si₂

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 2 h / 60 °C

2: imidazole / dimethylformamide / 1 h / Ambient temperature

3: 73 percent / PhCH₂NMe₃OH / CH₂Cl₂ / -78 - -10 °C

4: 1.) DCC, PP / 1.) toluene, RT, 5 min, 2.) toluene

With 1H-imidazole; N-benzyl-trimethylammonium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980229d

Reference yield:

: 114655-02-6
2'-O-(tert-butyldimethylsilyl)paclitaxel

: 1055033-93-6
C₅₇H₈₃NO₁₄Si₂

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 1 h / Ambient temperature

2: 73 percent / PhCH₂NMe₃OH / CH₂Cl₂ / -78 - -10 °C

3: 1.) DCC, PP / 1.) toluene, RT, 5 min, 2.) toluene

With 1H-imidazole; N-benzyl-trimethylammonium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980229d

Reference yield:

: 156413-61-5
2'-(tert-butyldimethylsilyl)-7-(triethylsilyl)paclitaxel

: 1055033-93-6
C₅₇H₈₃NO₁₄Si₂

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / PhCH₂NMe₃OH / CH₂Cl₂ / -78 - -10 °C

2: 1.) DCC, PP / 1.) toluene, RT, 5 min, 2.) toluene

With N-benzyl-trimethylammonium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm980229d