1-Methyl-3-thien-2-yl-5-(trifluoromethyl)-1H-pyrazole

Base Information

• Chemical Name: 1-Methyl-3-thien-2-yl-5-(trifluoromethyl)-1H-pyrazole
• CAS No.: 650615-64-8
• Molecular Formula: C9H7F3N2S
• Molecular Weight: 232.2254896
• Hs Code.: 2933199090
• Mol file: 650615-64-8.mol

Synonyms:1-Methyl-3-thien-2-yl-5-(trifluoromethyl)-1H-pyrazole

Chemical Property of 1-Methyl-3-thien-2-yl-5-(trifluoromethyl)-1H-pyrazole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-Methyl-3-thien-2-yl-5-(trifluoromethyl)-1H-pyrazole ^*data from reagent suppliers

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Technology Process of 1-Methyl-3-thien-2-yl-5-(trifluoromethyl)-1H-pyrazole

There total 2 articles about 1-Methyl-3-thien-2-yl-5-(trifluoromethyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

thiophene boronic acid (6165-68-0) + 1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl trifluoromethanesulfonate (623577-52-6) → 1-methyl-3-(2-thienyl)-5-(trifluoromethyl)pyrazole (650615-64-8)

Guidance literature:

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 100 ℃; for 14h; High pressure; Inert atmosphere;

DOI:10.1021/acschemneuro.7b00282

Reference yield:

5-trifluoromethyl-3-hydroxy-1-methylpyrazole (119022-51-4) → 1-methyl-3-(2-thienyl)-5-(trifluoromethyl)pyrazole (650615-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.08 h / -10 °C / Inert atmosphere

1.2: 1.28 h / -10 - 20 °C / Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / 1,4-dioxane / 14 h / 100 °C / High pressure; Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In 1,4-dioxane; dichloromethane; 2.1: |Suzuki-Miyaura Coupling;

DOI:10.1021/acschemneuro.7b00282

upstream raw materials:

5-trifluoromethyl-3-hydroxy-1-methylpyrazole

thiophene boronic acid

1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl trifluoromethanesulfonate

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