Ethyl pyrrolo[1,2-a]pyrazine-3-carboxylate

Base Information

• Chemical Name: Ethyl pyrrolo[1,2-a]pyrazine-3-carboxylate
• CAS No.: 153780-28-0
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.1986
• Hs Code.: 2933990090
• Mol file: 153780-28-0.mol

Synonyms:Ethyl pyrrolo[1,2-a]pyrazine-3-carboxylate;Pyrrolo[1,2-a]pyrazine-3-carboxylic acid ethyl ester

Chemical Property of Ethyl pyrrolo[1,2-a]pyrazine-3-carboxylate

Chemical Property:

• PSA: 43.60000
• LogP: 1.51100

Purity/Quality:

98% ^*data from raw suppliers

Pyrrolo1,2-apyrazine-3-carboxylicAcidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl pyrrolo[1,2-a]pyrazine-3-carboxylate

There total 3 articles about Ethyl pyrrolo[1,2-a]pyrazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

3,3-Diethoxy-2-{[1-[1-(toluene-4-sulfonyl)-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-amino}-propionic acid ethyl ester → ethyl pyrrolo(1,2-a)pyrazine-3-carboxylate (153780-28-0) + ethyl 2-(p-toluenesulfonylamino)-3-ethoxyacrylate

Guidance literature:

With PPA; trichlorophosphate; In toluene; at 120 ℃; for 0.25h;

DOI:10.1016/S0040-4020(01)88033-9

Reference yield: 24.0%

ethyl 3-ethoxy-O-ethyl-N-(1H-pyrrol-2-ylmethylene)serinate (711085-20-0) → ethyl pyrrolo(1,2-a)pyrazine-3-carboxylate (153780-28-0)

Guidance literature:

With trifluoroacetic acid; trichlorophosphate; In 1,2-dichloro-ethane; at 65 ℃; for 18h;

Reference yield: 24.0%

ethyl 3-ethoxy-O-ethyl-N(1H-pyrrol-2-ylmethylerie)serinate → ethyl pyrrolo(1,2-a)pyrazine-3-carboxylate (153780-28-0)

Guidance literature:

ethyl 3-ethoxy-O-ethyl-N(1H-pyrrol-2-ylmethylerie)serinate; With trifluoroacetic acid; trichlorophosphate; In 1,2-dichloro-ethane; at 65 ℃; for 18h;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane; at 20 ℃; pH=9;

upstream raw materials:

ethyl 3-ethoxy-O-ethyl-N-(1H-pyrrol-2-ylmethylene)serinate

Downstream raw materials:

ethyl 6-bromopyrrolo[1,2-a]pyrazine-3-carboxylate

Refernces

• 1、 -. "Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease". Page 54. . Retrieved 2010/02/06.