6-Cyclopropylnicotinic acid

Base Information

• Chemical Name: 6-Cyclopropylnicotinic acid
• CAS No.: 75893-75-3
• Molecular Formula: C9H9NO2
• Molecular Weight: 163.176
• Hs Code.: 2933399090
• European Community (EC) Number: 812-247-9
• DSSTox Substance ID: DTXSID30498335
• Wikidata: Q82348331
• Mol file: 75893-75-3.mol

Synonyms:6-cyclopropylnicotinic acid;75893-75-3;6-CYCLOPROPYLPYRIDINE-3-CARBOXYLIC ACID;MFCD18255573;6-cyclopropylnicotinicacid;SCHEMBL14822500;DTXSID30498335;AZQLYGCISPLJER-UHFFFAOYSA-N;AKOS016011099;AB74679;6-Cyclppropylpyridine-3-carboxylic acid;DS-15587;SY114534;O11587;EN300-1628116;A865598;J-518674;F2167-4838

Chemical Property of 6-Cyclopropylnicotinic acid

Chemical Property:

• Boiling Point: 338.6±30.0 °C(Predicted)
• PKA: 2.41±0.10(Predicted)
• PSA: 50.19000
• Density: 1.324±0.06 g/cm3(Predicted)
• LogP: 1.65720
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 163.063328530
• Heavy Atom Count: 12
• Complexity: 189

Purity/Quality:

97% ^*data from raw suppliers

6-CyclopropylnicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1C2=NC=C(C=C2)C(=O)O

Technology Process of 6-Cyclopropylnicotinic acid

There total 1 articles about 6-Cyclopropylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-cyclopropylpyridine-3-carboxylic acid (75893-75-3)

Guidance literature:

With water; sodium hydroxide; In ethanol; for 20h; Reflux;

Reference yield: 87.0%

6-cyclopropylpyridine-3-carboxylic acid (75893-75-3) + 5-[(2R,3R)-3-amino-2-methylpiperidin-1-yl]-3-{[4-(oxan-4-yloxy)phenyl]amino}pyrazine-2-carbonitrile → N-[(2R,3R)-1-(5-cyano-6-{[4-(oxan-4-yloxy)phenyl]amino}pyrazin-2-yl)-2-methylpiperidin-3-yl]-6-cyclopropylpyridine-3-carboxamide

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield: 35.0%

3-bromo-2-[[tert-butyl(dimethyl)silyl]oxymethyl] aniline (1147531-04-1) + 6-cyclopropylpyridine-3-carboxylic acid (75893-75-3) → N-[3-bromo-2-[[tert-butyl(dimethyl)silyl]oxymethyl]phenyl]-6-cyclopropylpyridine-3-carboxamide

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h;

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