HPI-1 Hydrate

Base Information

• Chemical Name: HPI-1 Hydrate
• CAS No.: 1262770-72-8
• Molecular Formula: C27H31NO7
• Molecular Weight: 481.53754
• Mol file: 1262770-72-8.mol

Synonyms:HPI-1 Hydrate;1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-Methoxyphenyl)-2-Methyl-5-oxo-3-quinolinecarboxylic Acid 2-Methoxyethyl Ester Hydrate

Chemical Property of HPI-1 Hydrate

Chemical Property:

• PSA: 103.32000
• LogP: 4.21650

Purity/Quality:

95% ^*data from raw suppliers

HPI-1 hydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 μM) without significantly affecting Wnt signaling (IC50 ≥ 30 μM). HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor. HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.
• Uses: HPI-1 is a Hedgehog pathway inhibitor; Gli1/Gli2 inhibitor.