N-((5-(4-chloroquinazolin-6-yl)furan-2-yl)Methyl)-2-(Methylsulfonyl)ethanaMine

Base Information

Chemical Name:N-((5-(4-chloroquinazolin-6-yl)furan-2-yl)Methyl)-2-(Methylsulfonyl)ethanaMine
CAS No.:1334953-75-1
Molecular Formula:C16H16ClN3O3S
Molecular Weight:365.84
Hs Code.:
Mol file:1334953-75-1.mol

Synonyms:N-((5-(4-chloroquinazolin-6-yl)furan-2-yl)Methyl)-2-(Methylsulfonyl)ethanaMine

Suppliers and Price of N-((5-(4-chloroquinazolin-6-yl)furan-2-yl)Methyl)-2-(Methylsulfonyl)ethanaMine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 11 raw suppliers

Chemical Property of N-((5-(4-chloroquinazolin-6-yl)furan-2-yl)Methyl)-2-(Methylsulfonyl)ethanaMine

Chemical Property:

Boiling Point:583.4±50.0 °C(Predicted)
PKA:6.31±0.19(Predicted)
PSA：93.47000
Density:1.376±0.06 g/cm3(Predicted)
LogP:4.14910

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-((5-(4-chloroquinazolin-6-yl)furan-2-yl)Methyl)-2-(Methylsulfonyl)ethanaMine

There total 7 articles about N-((5-(4-chloroquinazolin-6-yl)furan-2-yl)Methyl)-2-(Methylsulfonyl)ethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1334953-74-0
6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-ol

: 1334953-75-1
N-((5-(4-chloro-quinazoline-6-yl)furan-2-yl)methyl)-2-methylsulfonyl ethylamine

Guidance literature:: 6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-ol; With trichlorophosphate; In toluene; at 20 ℃; for 0.166667h; Inert atmosphere;

With triethylamine; In toluene; at 30 - 75 ℃; for 3h;

Reference yield:

: 1334953-74-0
6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4(3H)-one

: 1334953-75-1
N-((5-(4-chloro-quinazoline-6-yl)furan-2-yl)methyl)-2-methylsulfonyl ethylamine

Guidance literature:: With triethylamine; trichlorophosphate; In toluene; at 90 ℃; for 2h;

Reference yield:

: 16064-08-7
6-iodo-4-hydroxyquinazoline

: 1334953-75-1
N-((5-(4-chloro-quinazoline-6-yl)furan-2-yl)methyl)-2-methylsulfonyl ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / toluene / 110 - 115 °C / Molecular sieve; Inert atmosphere

2.1: potassium carbonate / triphenyl-arsane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 60 - 65 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere

3.2: 2 h / 20 - 25 °C

4.1: toluene-4-sulfonic acid / methanol / 1 h / 25 °C

5.1: trichlorophosphate / toluene / 0.17 h / 20 °C / Inert atmosphere

5.2: 3 h / 30 - 75 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane; toluene-4-sulfonic acid; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;