Trans-Methyl 1-benzyl-4-p-tolylpyrrolidine-3-carboxylate

Base Information

Chemical Name:Trans-Methyl 1-benzyl-4-p-tolylpyrrolidine-3-carboxylate
CAS No.:898547-79-0
Molecular Formula:C₂₀H₂₃NO₂
Molecular Weight:309.408
Hs Code.:
Mol file:898547-79-0.mol

Synonyms:Trans-Methyl 1-benzyl-4-p-tolylpyrrolidine-3-carboxylate;(3R,4S)-Methyl 1-benzyl-4-(p-tolyl)pyrrolidine-3-carboxylate

Suppliers and Price of Trans-Methyl 1-benzyl-4-p-tolylpyrrolidine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(3R,4S)-Methyl1-benzyl-4-(p-tolyl)pyrrolidine-3-carboxylate 95+%
1g
$ 589.00

Chemenu
(3R,4S)-Methyl1-benzyl-4-(p-tolyl)pyrrolidine-3-carboxylate 95%
1g
$ 496.00

Alichem
(3R,4S)-Methyl1-benzyl-4-(p-tolyl)pyrrolidine-3-carboxylate
1g
$ 567.10

Total 4 raw suppliers

Chemical Property of Trans-Methyl 1-benzyl-4-p-tolylpyrrolidine-3-carboxylate

Chemical Property:

PSA：29.54000
LogP:3.32150

Purity/Quality:

95-326%min ^*data from raw suppliers

(3R,4S)-Methyl1-benzyl-4-(p-tolyl)pyrrolidine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Trans-Methyl 1-benzyl-4-p-tolylpyrrolidine-3-carboxylate

There total 3 articles about Trans-Methyl 1-benzyl-4-p-tolylpyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₁₀H₉FO

: 93102-05-7
N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

: 898547-79-0
(3SR,4SR)methyl 1-benzyl-4-(p-tolyl)pyrrolidine-3-carboxylate

Guidance literature:: With dmap; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Mechanism; Inert atmosphere;
DOI:10.1039/c2ob26047f

Reference yield:

: 20754-20-5
3-p-tolyl-acrylic acid methyl ester

: 93102-05-7
N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

: 898547-79-0
(3SR,4SR)methyl 1-benzyl-4-(p-tolyl)pyrrolidine-3-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃;
DOI:10.1016/j.bmcl.2005.06.033

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 898547-79-0
(3SR,4SR)methyl 1-benzyl-4-(p-tolyl)pyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 4 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C

With trifluoroacetic acid; In dichloromethane; 1: |Wittig Olefination;
DOI:10.1021/acs.jmedchem.8b01972