Cyclododecaneacetonitrile

Base Information

• Chemical Name: Cyclododecaneacetonitrile
• CAS No.: 21963-16-6
• Molecular Formula: C14H25N
• Molecular Weight: 207.359
• Mol file: 21963-16-6.mol

Synonyms:Cyclododecaneacetonitrile

Chemical Property of Cyclododecaneacetonitrile

Chemical Property:

• PSA: 23.79000
• LogP: 4.82098

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclododecaneacetonitrile

There total 4 articles about Cyclododecaneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclododecenylideneacetonitrile (64723-66-6) → 2-cyclododecylacetonitrile (21963-16-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 3000.3 Torr; Inert atmosphere;

DOI:10.1039/c9cc01330j

Reference yield:

cyclododecanone (830-13-7) → 2-cyclododecylacetonitrile (21963-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

1.2: 12 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / 3000.3 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; methanol; mineral oil;

DOI:10.1039/c9cc01330j

Reference yield:

diethyl 1-cyanomethylphosphonate (2537-48-6) + cyclododecanone (830-13-7) → 2-cyclododecylacetonitrile (21963-16-6)

Guidance literature:

Multistep reaction; (i) , (ii) (catalytic hydrogenation);

DOI:10.1002/hlca.19780610727

upstream raw materials:

diethyl 1-cyanomethylphosphonate

cyclododecanone

cyclododecenylideneacetonitrile

Downstream raw materials:

cyclodecylethanal

cyclododecanecarboxylic acid

Refernces

• 1、 Fischli. "Cob(I)alamine as catalyst. I. Communication. Reduction of saturated nitriles in aqueous solution". . p. 2560 - 2578. Retrieved 2007/10/08.