1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:120086-35-3
Molecular Formula:C13H13NS
Molecular Weight:215.319
Hs Code.:2934999090
DSSTox Substance ID:DTXSID40383147
ChEMBL ID:CHEMBL21830
Mol file:120086-35-3.mol

Synonyms:1-(thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline;120086-35-3;1-Thiophen-2-yl-1,2,3,4-tetrahydro-isoquinoline;1-(2-thienyl)-1,2,3,4-tetrahydroisoquinoline;1-thiophen-2-yl-1,2,3,4-tetrahydroisoquinoline;CHEMBL21830;AF-399/42531577;SCHEMBL2330566;DTXSID40383147;FHDLSGWIMXIQQV-UHFFFAOYSA-N;BDBM50017055;STL224110;AKOS000267421;AKOS016038988;CS-0324813;BRD-A36863360-001-01-8

Suppliers and Price of 1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline
50mg
$ 90.00

Matrix Scientific
1-Thiophen-2-yl-1,2,3,4-tetrahydro-isoquinoline
500mg
$ 250.00

Matrix Scientific
1-Thiophen-2-yl-1,2,3,4-tetrahydro-isoquinoline
1g
$ 386.00

Chemenu
1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline 97%
5g
$ 808.00

Arctom
1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline 97%
1g
$ 264.00

American Custom Chemicals Corporation
1-(2-THIENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE 95.00%
500MG
$ 796.95

AK Scientific
1-Thiophen-2-yl-1,2,3,4-tetrahydro-isoquinoline
500mg
$ 387.00

Total 4 raw suppliers

Chemical Property of 1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

PSA：40.27000
LogP:3.31200
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:215.07687059
Heavy Atom Count:15
Complexity:219

Purity/Quality:

98%min ^*data from raw suppliers

1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNC(C2=CC=CC=C21)C3=CC=CS3

Technology Process of 1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92059-63-7
1-(thiophen-2-yl)-3,4-dihydroisoquinoline

: 120086-35-3
1-(2-thienyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 20h; Yield given; Heating;
DOI:10.1021/jm00126a016

Reference yield:

: 75690-78-7
N-(2-phenylethyl)thiophene-2-carboxamide

: 120086-35-3
1-(2-thienyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: P₂O₅; POCl₃ / xylene / 2.5 h / Heating

2: NaBH₄ / ethanol / 60 h / 20 °C

With sodium tetrahydroborate; phosphorus pentoxide; trichlorophosphate; In ethanol; xylene;
DOI:10.1021/jm050099q

Reference yield:

: 5271-67-0
2-Thiophenecarbonyl chloride

: 120086-35-3
1-(2-thienyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / CH₂Cl₂ / 4 h / Ambient temperature

2: POCl₃, P₂O₅ / 2 h / Heating

3: LiAlH₄ / diethyl ether / 20 h / Heating

With lithium aluminium tetrahydride; phosphorus pentoxide; trichlorophosphate; In diethyl ether; dichloromethane;
DOI:10.1021/jm00126a016