N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]-Thiourea

Base Information

Chemical Name:N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]-Thiourea
CAS No.:1314743-49-1
Molecular Formula:C19H23F6N3S
Molecular Weight:439.4614392
Hs Code.:
Mol file:1314743-49-1.mol

Synonyms:N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]-Thiourea;1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(1R,2R)-2- (pyrrolidin-1-yl)cyclohexyl]thiourea

Suppliers and Price of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]-Thiourea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]thiourea, 98%, (99% ee) (99% ee)
50mg
$ 100.00

ChemScene
1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]thiourea ≥97.0%
100mg
$ 99.00

Arctom
1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl)thiourea 97%
100mg
$ 181.00

Total 9 raw suppliers

Chemical Property of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]-Thiourea

Chemical Property:

Boiling Point:413.0±55.0 °C(Predicted)
PKA:11.76±0.70(Predicted)
Density:1.36±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]thiourea, 98%, (99% ee) (99% ee) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]-Thiourea

There total 4 articles about N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]-Thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: C₁₁H₂₁N

: 1314743-49-1
1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl)thiourea

Guidance literature:: In dichloromethane; Reflux;
DOI:10.1002/anie.201706150

Reference yield:

: 885677-92-9
(1R,2R)-2-(pyrrolidin-1-yl)cyclohexan-1-amine

: isothiocyanato-3,5-bis(trifluoromethyl)benzene

: 1314743-49-1
1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl)thiourea

Guidance literature:: (1R,2R)-2-(pyrrolidin-1-yl)cyclohexan-1-amine; With hydrogenchloride; In water; at 150 ℃; for 1h; Microwave irradiation;

isothiocyanato-3,5-bis(trifluoromethyl)benzene; With triethylamine; In tetrahydrofuran; for 2h;