Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate

Base Information

• Chemical Name: Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate
• CAS No.: 319442-19-8
• Molecular Formula: C9H8N2O3S
• Molecular Weight: 224.23642
• Hs Code.: 2934999090
• Mol file: 319442-19-8.mol

Synonyms:Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate

Chemical Property of Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate

Chemical Property:

• PSA: 100.29000
• LogP: 1.16130
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-2-carboxylate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate

There total 5 articles about Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

oxalic acid diethyl ester (95-92-1) + 3-aminothiophene-2-carboxamide (147123-47-5) → ethyl 4-oxothieno[3,2-d]pyrimidine-2-carboxylate (319442-19-8)

Guidance literature:

With sodium ethanolate; In ethanol; for 18h; Heating / reflux;

Reference yield: 63.0%

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) + ethyl cyanoformate (623-49-4) → ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-2-carboxylate (319442-19-8)

Guidance literature:

With hydrogenchloride; In water; acetic acid; at 70 ℃; for 3h;

Reference yield: 19.0%

ethyl 4-oxo-3,4-dihydrothieno[3,2-d]-1,3-oxazine-2-carboxylate → ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-2-carboxylate (319442-19-8)

Guidance literature:

With ammonium acetate; In ethanol; for 1h; Reflux;

DOI:10.1016/j.bmc.2014.07.025

upstream raw materials:

oxalic acid diethyl ester

3-aminothiophene-2-carboxamide

Methyl 3-aminothiophene-2-carboxylate

ethyl cyanoformate

Downstream raw materials:

ethyl 4-chlorothieno[3,2-d]pyrimidine-2-carboxylate

1-(4-fluorophenyl)-1-(4-(5-methyl-1H-pyrazol-3-ylamino)thieno[3,2-d]pyrimidin-2-yl)ethanol

2-((4-fluorophenyl)(methoxy)methyl)-N-(5-methyl-1H-pyrazol-3-yl)thieno[3,2-d]pyrimidin-4-amine

(4-chlorothieno[3,2-d]pyrimidin-2-yl)(4-fluorophenyl)methanone

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