1-(2,6-dichlorophenyl)ethanaMine hydrochloride

Base Information

• Chemical Name: 1-(2,6-dichlorophenyl)ethanaMine hydrochloride
• CAS No.: 172699-35-3
• Molecular Formula: C₈H₉Cl₂N
• Molecular Weight: 190.072
• Hs Code.: 2921499090
• Mol file: 172699-35-3.mol

Synonyms:1-(2,6-dichlorophenyl)ethanaMine hydrochloride;1-(2,6-dichlorophenyl)ethanaMine;1-(2,6-DICHLORO-PHENYL)-ETHYLAMINE

Chemical Property of 1-(2,6-dichlorophenyl)ethanaMine hydrochloride

Chemical Property:

• Boiling Point: 248.1±25.0 °C(Predicted)
• PKA: 7.96±0.10(Predicted)
• PSA: 26.02000
• Density: 1.262±0.06 g/cm3(Predicted)
• LogP: 4.51540

Purity/Quality:

97% ^*data from raw suppliers

1-(2,6-Dichlorophenyl)ethanaminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,6-dichlorophenyl)ethanaMine hydrochloride

There total 11 articles about 1-(2,6-dichlorophenyl)ethanaMine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

1-(2-Chloro-phenyl)-ethylamine (39959-67-6,68285-26-7,127733-42-0,127852-23-7) → 1-(2,6-dichlorophenyl)ethan-1-amine (1131737-05-7,172699-35-3)

Guidance literature:

With copper diacetate; palladium diacetate; copper dichloride; In acetic acid; at 100 ℃; for 14h;

DOI:10.1055/a-1625-9095

Reference yield:

(1S)-N-Trimethylsilyl-1-(2-chlorophenyl)ethylamine (121443-78-5) → (1S)-(-)-1-(2,6-Dichlorophenyl)ethylamine (121443-79-6,1131737-05-7,172699-35-3)

Guidance literature:

With n-butyllithium; hexachloroethane; Yield given. Multistep reaction; 1.) ether, hexane, 0 deg C, 40 min, 2.) ether, hexane, -40 deg C, 1 h;

DOI:10.1021/ja00195a044

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → (1S)-(-)-1-(2,6-Dichlorophenyl)ethylamine (121443-79-6,1131737-05-7,172699-35-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / (NH₄)2SO₄ / 1.) 100 deg C, 5 h; 125 deg C, 19 h, 2.) TMSCl was added to complete conversion at 25 deg C, then 125 deg C, 12 h

2: 1.) n-BuLi, 2.) hexachloroethane / 1.) ether, hexane, 25 deg C, 24 h, 2.) ether, hexane, -40 deg C, 1 h

3: 83 percent / (NH₄)2SO₄ / 1.) 100 deg C, 5 h; 125 deg C, 19 h, 2.) TMSCl was added to complete conversion at 25 deg C, then 125 deg C, 12 h

4: 1.) n-BuLi, 2.) hexachloroethane / 1.) ether, hexane, 0 deg C, 40 min, 2.) ether, hexane, -40 deg C, 1 h

With ammonium sulfate; n-butyllithium; hexachloroethane;

DOI:10.1021/ja00195a044

upstream raw materials:

(1S)-N-Trimethylsilyl-1-(2-chlorophenyl)ethylamine

(S)-1-phenyl-ethylamine

(S)-α-(o-chlorophenyl)ethylamine

N-<(S)-1-phenylethyl>(trimethylsilyl)amine