1,4-Bis(2,3,4-trimethoxybenzyl)piperazine

Base Information

• Chemical Name: 1,4-Bis(2,3,4-trimethoxybenzyl)piperazine
• CAS No.: 1257-19-8
• Molecular Formula: C24H34N2O6
• Molecular Weight: 446.544
• UNII: CN4K7E3V8E
• DSSTox Substance ID: DTXSID40386830
• Wikidata: Q82180529
• Mol file: 1257-19-8.mol

Synonyms:Hexametazidine;1,4-bis(2,3,4-trimethoxybenzyl)piperazine;1257-19-8;1,4-bis[(2,3,4-trimethoxyphenyl)methyl]piperazine;CN4K7E3V8E;UNII-CN4K7E3V8E;1,4-Bis((2,3,4-trimethoxyphenyl)methyl)piperazine;Piperazine, 1,4-bis((2,3,4-trimethoxyphenyl)methyl)-;Trimetazidine dihydrochloride impurity B [EP];Trimetazidine Impurity B;DTXSID40386830;BCP33736;STK211948;AKOS000553731;CS-0165172;1,4-Bis(2,3,4-trimethoxybenzyl)piperazine;TRIMETAZIDINE DIHYDROCHLORIDE IMPURITY B [EP IMPURITY];1,4-bis(2,3,4-trimethoxybenzyl)piperazine? (Trimetazidine Impurity pound(c)

Chemical Property of 1,4-Bis(2,3,4-trimethoxybenzyl)piperazine

Chemical Property:

• Melting Point: 108-109℃
• PSA: 61.86000
• LogP: 2.93180
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly, Heated)
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 10
• Exact Mass: 446.24168681
• Heavy Atom Count: 32
• Complexity: 487

Purity/Quality:

99% ^*data from raw suppliers

Hexametazidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C(C=C1)CN2CCN(CC2)CC3=C(C(=C(C=C3)OC)OC)OC)OC)OC
• Uses: Hexametazidine is an impurity of Trimetazidine (T795610). Trimetazidine impurity B. Hexametazidine can protect the myocardium from injury by ischemia and reperfusion. Hexametazidine is an impurity of Trimetazidine (T795610). Trimetazidine impurity B. Hexametazidine can protect the myocardium from injury by ischemia and reperfusion.

Technology Process of 1,4-Bis(2,3,4-trimethoxybenzyl)piperazine

There total 2 articles about 1,4-Bis(2,3,4-trimethoxybenzyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.4%

piperazine (110-85-0) + 2,3,4-trimethoxybenzaldehyde (2103-57-3) → N,N-[(2,3,4-trimethoxyphenyl)dimethyl]piperazine (1257-19-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 50 - 60 ℃; under 3750.38 Torr; Solvent; Autoclave;

Reference yield:

→ N,N-[(2,3,4-trimethoxyphenyl)dimethyl]piperazine (1257-19-8)

Guidance literature:

2,3,4-(MeO)3-C6H2CH2Cl (II), N-(2,3,4-Trimethoxy-benzyl)-piperazin (IV), K2CO3, in Toluol, Rueckfluss;

upstream raw materials:

piperazine

2,3,4-trimethoxybenzaldehyde