10H-pyrido[4,3-b][1,4]benzothiazine

Base Information

• Chemical Name: 10H-pyrido[4,3-b][1,4]benzothiazine
• CAS No.: 261-92-7
• Molecular Formula: C16H13ClN2O2
• Molecular Weight: 200.264
• Mol file: 261-92-7.mol

Synonyms:4-[3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid;p-[3-(p-Chlorophenyl)-2-pyrazolin-1-yl]benzoic acid;Benzoic acid,4-[3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-

Chemical Property of 10H-pyrido[4,3-b][1,4]benzothiazine

Chemical Property:

• Vapor Pressure: 1.13E-06mmHg at 25°C
• Boiling Point: 402.1°C at 760 mmHg
• Flash Point: 197°C
• Density: 1.293g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10H-pyrido[4,3-b][1,4]benzothiazine

There total 7 articles about 10H-pyrido[4,3-b][1,4]benzothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

→ 5H-pyrido[2,3-b][1,4]benzothiazine (261-93-8) + 10H-pyrido<4,3-b><1,4>benzothiazine (261-92-7)

Guidance literature:

Reference yield:

4-(2-bromo-phenylsulfanyl)-[3]pyridylamine (104093-30-3) → 10H-pyrido<4,3-b><1,4>benzothiazine (261-92-7)

Guidance literature:

With copper(l) iodide; sodium sulfite; at 180 - 190 ℃;

DOI:10.1021/jo01106a022

Reference yield:

4-(2-bromo-phenylsulfanyl)-3-nitro-pyridine (103988-65-4) → 10H-pyrido<4,3-b><1,4>benzothiazine (261-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SnCl₂; aqueous HCl

2: CuI; Na₂SO₃ / 180 - 190 °C

With hydrogenchloride; copper(l) iodide; tin(ll) chloride; sodium sulfite;

DOI:10.1021/jo01106a022

upstream raw materials:

4-(2-bromo-phenylsulfanyl)-[3]pyridylamine

3-nitro-4-(phenylthio)pyridine

4-(2-bromo-phenylsulfanyl)-3-nitro-pyridine

4-chloro-3-nitropyridine

Downstream raw materials:

9-(3-Pyrrolidin-1-yl-propyl)-9H-10-thia-2,9-diaza-anthracene