3-hydroxy-3-Methylcyclobutanecarboxylic acid

Base Information

• Chemical Name: 3-hydroxy-3-Methylcyclobutanecarboxylic acid
• CAS No.: 16286-86-5
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.144
• Mol file: 16286-86-5.mol

Synonyms:3-hydroxy-3-Methylcyclobutanecarboxylic acid;3-hydroxy-3-methylcyclobutane-1-carboxylic acid

Chemical Property of 3-hydroxy-3-Methylcyclobutanecarboxylic acid

Chemical Property:

• Boiling Point: 270.4±33.0 °C(Predicted)
• PKA: 4.55±0.40(Predicted)
• Density: 1.319±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Hydroxy-3-methylcyclobutanecarboxylic 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-hydroxy-3-Methylcyclobutanecarboxylic acid

There total 1 articles about 3-hydroxy-3-Methylcyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-hydroxy-3-methylcyclobutanecarboxylic acid (16286-86-5,1384855-41-7,1314970-28-9)

Guidance literature:

aus entspr. Nitril;

Reference yield: 30.0%

3-hydroxy-3-methylcyclobutanecarboxylic acid (16286-86-5,1384855-41-7,1314970-28-9) + 6-(1-(6-methyl-5-(trifluoromethyl)pyridin-2-yl)ethyl)-2-azaspiro[3.3]heptane → (rac)-((1s,3s)-3-hydroxy-3-methylcyclobutyl)(6-(1-(6-methyl-5-(trifluoromethyl)pyridin-2-yl)ethyl)-2-azaspiro[3.3]heptan-2-yl)methanone + SiO2 (7631-86-9,105269-70-3,1317-48-2,13778-37-5,14464-46-1,14808-60-7,14832-85-0,15468-32-3,17679-64-0,87347-84-0,92283-58-4,99439-28-8,15723-40-7)

Guidance literature:

With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;

Reference yield: 25.0%

3-hydroxy-3-methylcyclobutanecarboxylic acid (16286-86-5,1384855-41-7,1314970-28-9) + 6-(3-cyclopropyl-2-fluorophenyl)-2-azaspiro[3.4]oct-5-ene → (rac)-(6-(3-Cyclopropyl-2-fluorophenyl)-2-azaspiro[3.4]oct-5-en-2-yl)((1s,3s)-3-hydroxy-3-methylcyclobutyl)methanone + SiO2 (7631-86-9,105269-70-3,1317-48-2,13778-37-5,14464-46-1,14808-60-7,14832-85-0,15468-32-3,17679-64-0,87347-84-0,92283-58-4,99439-28-8,15723-40-7)

Guidance literature:

With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;

Downstream raw materials:

SiO₂