1,2:3,5-DI-O-ISOPROPYLIDENE-ALPHA-D-APIOSE

Base Information

• Chemical Name: 1,2:3,5-DI-O-ISOPROPYLIDENE-ALPHA-D-APIOSE
• CAS No.: 25904-06-7
• Molecular Formula: C₁₁H₁₈O₅
• Molecular Weight: 230.261
• Hs Code.: 29400090
• Mol file: 25904-06-7.mol

Synonyms:1,2,3,5-DI-O-ISOPROPYLIDENE-ALPHA-D-APIOSE;1,2:3,5-DI-O-ISOPROPYLIDENE-ALPHA-D-APIOSE;ALPHA-D-APIOSE DIACETONIDE;ALPHA-DIACETONE-D-APIOSE;1,2:3,5-di-O-isopropylidene-A-D-apiose;1,2:3,5-Di-O-isopropylidene;α-d-apiose diacetonide;1,2:5,6-DI-O-ISOPROPYLIDENE-A-D-APIOSE

Chemical Property of 1,2:3,5-DI-O-ISOPROPYLIDENE-ALPHA-D-APIOSE

Chemical Property:

• Vapor Pressure: 0.00731mmHg at 25°C
• Melting Point: 82°C
• Boiling Point: 278.2°C at 760 mmHg
• Flash Point: 107.1°C
• PSA: 46.15000
• Density: 1.22g/cm³
• LogP: 1.01590
• Storage Temp.: −20°C

Purity/Quality:

98%Min ^*data from raw suppliers

1,2:3,5-Di-O-isopropylidene-a-D-apiose ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2:3,5-DI-O-ISOPROPYLIDENE-ALPHA-D-APIOSE

There total 2 articles about 1,2:3,5-DI-O-ISOPROPYLIDENE-ALPHA-D-APIOSE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1,2:3,5-di-O-isopropylidene-α-D-threo-apiofuranose (25904-06-7,34724-16-8,96554-32-4)

Guidance literature:

aus Acetal 6, 1) H⁺, 2) Aceton/H2SO4;

DOI:10.1016/S0008-6215(00)81094-0

Reference yield:

→ 1,2;3,5-Di-O-isopropyliden-α-D-apiofuranose (25904-06-7,34724-16-8,96554-32-4)

Guidance literature:

Aus Pentital 4, 1) Acetobacter antioxydans (-> Ketose 5), 2)Austauscher (H⁺)/Aceton;

DOI:10.1016/S0008-6215(00)85458-0

Reference yield:

1,2:3,5-di-O-isopropylidene-α-D-threo-apiofuranose (25904-06-7,34724-16-8,96554-32-4) → ethyl 2,3-di-O-acetyl-5-O-benzyl-1-thio-β-D-erythro-apiofuranoside

Guidance literature:

Multi-step reaction with 4 steps

1.1: 81 percent / HCl / methanol / 20 °C

2.1: 82 percent / NaH / dimethylformamide / 20 °C

3.1: aq. HCOOH / 60 °C

3.2: DMAP; pyridine / 20 °C

4.1: SnCl₄ / CH₂Cl₂ / 0.5 h / 0 °C

With hydrogenchloride; formic acid; tin(IV) chloride; sodium hydride; In methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Hydrolysis / 2.1: Alkylation / 3.1: Hydrolysis / 3.2: Acetylation / 4.1: Substitution;

DOI:10.1016/S0040-4020(99)00527-X

Downstream raw materials:

D-apiose

1,2,3-tri-O-acetyl-3-C-(benzyloxymethyl)-α/β-D-erythrofuranoside

(3S)-2-hydroxymethylbutane-1,2,3,4-tetrol