tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate

Base Information

Chemical Name:tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate
CAS No.:849470-63-9
Molecular Formula:C₂₈H₃₇FN₂O₆S
Molecular Weight:548.676
Hs Code.:
Mol file:849470-63-9.mol

Synonyms:tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate;(4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-(Methylsulfonyl)-5-pyriMidinyl]ethenyl]-2,2-diMethyl-1,3-dioxane-4-acetic Acid 1,1-DiMethylethyl Ester

Suppliers and Price of tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate
2.5mg
$ 120.00

Medical Isotopes, Inc.
tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate
2.5 mg
$ 860.00

American Custom Chemicals Corporation
TERT-BUTYL-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-METHYLSULFONYLPYRIMIDIN-5-YL]-(3R,5S)-ISOPROPYLIDENE-(E)-6-HEPTENOATE 95.00%
5MG
$ 503.37

Total 4 raw suppliers

Chemical Property of tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:663.302°C at 760 mmHg
Flash Point:354.953°C
PSA：113.06000
Density:1.193g/cm³
LogP:6.54560
Storage Temp.:Refrigerator
Solubility.:Chloroform, Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate

There total 3 articles about tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 380460-37-7
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

: 849470-61-7
4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carbaldehyde

: 849470-63-9
tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-acetate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/op100010n

Reference yield:

: 849470-59-3
(4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidin-5-yl)methanol

: 849470-63-9
tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hypochlorite; 2,2,6,6-tetramethylpiperidin-1-ol / water; ethyl acetate

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

With sodium hypochlorite; 2,2,6,6-tetramethylpiperidin-1-ol; lithium hexamethyldisilazane; In tetrahydrofuran; water; ethyl acetate; 2: Julia-Kocienski Olefin synthesis;
DOI:10.1021/op100010n

Reference yield:

: 147118-28-3
ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate

: 849470-63-9
tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane

2: sodium hypochlorite; 2,2,6,6-tetramethylpiperidin-1-ol / water; ethyl acetate

3: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

With sodium hypochlorite; 2,2,6,6-tetramethylpiperidin-1-ol; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 3: Julia-Kocienski Olefin synthesis;
DOI:10.1021/op100010n