A 1120

Base Information

Chemical Name:A 1120
CAS No.:1152782-19-8
Molecular Formula:C20H19F3N2O3
Molecular Weight:392.37
Hs Code.:
Mol file:1152782-19-8.mol

Synonyms:A 1120;2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

Suppliers and Price of A 1120

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
A 1120
10mg
$ 446.00

TRC
A1120
2.5mg
$ 220.00

Tocris
A1120 ≥99%(HPLC)
50
$ 785.00

Tocris
A1120 ≥99%(HPLC)
10
$ 186.00

Sigma-Aldrich
A1120 ≥98% (HPLC), powder
25mg
$ 472.00

Sigma-Aldrich
A1120 ≥98% (HPLC), powder
5mg
$ 126.00

DC Chemicals
A1120
002
$ 950.00

DC Chemicals
A1120
001
$ 550.00

DC Chemicals
A1120
004
$ 1900.00

ApexBio Technology
A1120
5mg
$ 441.00

Total 13 raw suppliers

Chemical Property of A 1120

Chemical Property:

Boiling Point:572.3±50.0 °C(Predicted)
PKA:4.03±0.36(Predicted)
PSA：73.13000
Density:1.370±0.06 g/cm3(Predicted)
LogP:4.76660
Storage Temp.:2-8°C

Purity/Quality:

99% ^*data from raw suppliers

A 1120 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn,N
Statements: 22-36-43-50/53
Safety Statements: 26-36/37-60-61

MSDS Files:: SDS file from LookChem

Useful:

Uses A 1120 is a a nonretinoid RBP4 antagonist, which inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis.

Technology Process of A 1120

There total 8 articles about A 1120 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1482429-12-8
C₂₁H₂₁F₃N₂O₃

: 1152782-19-8
2 (4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

Guidance literature:: C₂₁H₂₁F₃N₂O₃; With sodium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; d⁽⁴⁾-methanol; water; pH=6; Inert atmosphere;
DOI:10.1021/jm5010013

Reference yield: 66.0%

: 1793-07-3
methyl 2-isocyanatobenzoate

: 4-(2-(trifluoromethyl)phenyl)piperidine hydrochloride

: 1152782-19-8
2 (4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

Guidance literature:: methyl 2-isocyanatobenzoate; 4-(2-(trifluoromethyl)phenyl)piperidine hydrochloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 6h;

Reference yield: 66.0%

: 1793-07-3
methyl 2-isocyanatobenzoate

: 255051-14-0
4-[2-(trifluoromethyl)phenyl]piperidine hydrochloride

: 1152782-19-8
2 (4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

Guidance literature:: methyl 2-isocyanatobenzoate; 4-[2-(trifluoromethyl)phenyl]piperidine hydrochloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 0.25h;

With ethanol; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 6h;