3-AMino-5-broMo-2-ethylpyridine

Base Information

• Chemical Name: 3-AMino-5-broMo-2-ethylpyridine
• CAS No.: 1093819-32-9
• Molecular Formula: C7H9BrN2
• Molecular Weight: 201.066
• Mol file: 1093819-32-9.mol

Synonyms:3-AMino-5-broMo-2-ethylpyridine;5-bromo-2-ethyl-3-Pyridinamine;5-bromo-2-ethylpyridin-3-amine

Chemical Property of 3-AMino-5-broMo-2-ethylpyridine

Chemical Property:

• Boiling Point: 293.0±35.0 °C(Predicted)
• PKA: 4.47±0.20(Predicted)
• PSA: 38.91000
• Density: 1.501±0.06 g/cm3(Predicted)
• LogP: 2.56990

Purity/Quality:

98%min ^*data from raw suppliers

3-Amino-5-bromo-2-ethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMino-5-broMo-2-ethylpyridine

There total 3 articles about 3-AMino-5-broMo-2-ethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-bromo-2-ethyl-3-nitropyridine (1211591-74-0) → 5-bromo-2-ethylpyridin-3-amine (1093819-32-9)

Guidance literature:

With iron; acetic acid; In water; at 20 ℃; for 3h;

Reference yield:

5-bromo-2-chloro-3-nitropyridine (67443-38-3) → 5-bromo-2-ethylpyridin-3-amine (1093819-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C

1.2: 1 h / 20 °C

1.3: 100 °C

2.1: ammonium chloride; iron / water; ethanol / 80 °C

With iron; sodium hydride; ammonium chloride; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.ejmech.2021.114036

Reference yield:

→ 5-bromo-2-ethylpyridin-3-amine (1093819-32-9)

Guidance literature:

upstream raw materials:

5-bromo-2-ethyl-3-nitropyridine

5-bromo-2-chloro-3-nitropyridine

Refernces

• 1、 Dong, Jiaqiang,Huang, Jingjie,Zhou, Ji,Tan, Ye,Jin, Jing,Tan, Xi,Wang, Bei,Yu, Tao,Wu, Chengde,Chen, Shuhui,Wang, Tie-Lin. "Discovery of 3-Quinazolin-4(3 H)-on-3-yl-2, N-dimethylpropanamides as Orally Active and Selective PI3Kα Inhibitors". supporting information. p. 1463 - 1469. Retrieved 2020/08/14.
• 2、 -. "HETEROARYLS AND USES THEREOF". Paragraph 0310-0311. . Retrieved 2015/09/22.