R-2-(1,1-diMethylethyl)-1-[(4-Methylphenyl)sulfonyl]-Aziridine

Base Information

• Chemical Name: R-2-(1,1-diMethylethyl)-1-[(4-Methylphenyl)sulfonyl]-Aziridine
• CAS No.: 1207754-84-4
• Molecular Formula: C13H19NO2S
• Molecular Weight: 253.365
• Mol file: 1207754-84-4.mol

Synonyms:R-2-(1,1-diMethylethyl)-1-[(4-Methylphenyl)sulfonyl]-Aziridine

Chemical Property of R-2-(1,1-diMethylethyl)-1-[(4-Methylphenyl)sulfonyl]-Aziridine

Chemical Property:

• PSA: 45.53000
• LogP: 3.43270

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of R-2-(1,1-diMethylethyl)-1-[(4-Methylphenyl)sulfonyl]-Aziridine

There total 1 articles about R-2-(1,1-diMethylethyl)-1-[(4-Methylphenyl)sulfonyl]-Aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-2-amino-3,3-dimethylbutan-1-ol (3907-02-6,93684-72-1,112245-13-3,112245-09-7) + p-toluenesulfonyl chloride (98-59-9) → (2R)-2-(1,1-dimethylethyl)-1-[(4-methylphenyl)sulfonyl]-aziridine (1207754-84-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 40 ℃; for 18h; Inert atmosphere;

Reference yield: 14.0%

(Z)-4-(1,3-dithian-2-yl)but-2-en-1-ol (1197214-81-5) + (2R)-2-(1,1-dimethylethyl)-1-[(4-methylphenyl)sulfonyl]-aziridine (1207754-84-4) → C21H33NO3S3 (1265595-92-3)

Guidance literature:

(Z)-4-(1,3-dithian-2-yl)but-2-en-1-ol; With tert.-butyl lithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; pentane; at -78 ℃;

(2R)-2-(1,1-dimethylethyl)-1-[(4-methylphenyl)sulfonyl]-aziridine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; pentane; at -78 ℃; for 0.5h;

DOI:10.1021/ol103064f

Reference yield:

benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-hydroxy-14-methoxy-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate (956102-56-0) + (2R)-2-(1,1-dimethylethyl)-1-[(4-methylphenyl)sulfonyl]-aziridine (1207754-84-4) → benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-3,3-dimethyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate (1207755-49-4)

Guidance literature:

With 18-crown-6 ether; potassium hydride; In 1,2-dimethoxyethane; at 0 ℃; for 1h; Inert atmosphere;

upstream raw materials:

(2R)-2-amino-3,3-dimethylbutan-1-ol

p-toluenesulfonyl chloride

Downstream raw materials:

benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-3,3-dimethyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate

C₂₁H₃₃NO₃S₃

(R)-N-(1-methoxy-4-methylpentan-2-yl)-4-methylbenzenesulfonamide

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