3-(3-chloro-4-hydroxyphenyl)propanoic acid

Base Information

• Chemical Name: 3-(3-chloro-4-hydroxyphenyl)propanoic acid
• CAS No.: 79669-18-4
• Molecular Formula: C9H9ClO3
• Molecular Weight: 200.622
• Mol file: 79669-18-4.mol

Synonyms:3-(3-chloro-4-hydroxyphenyl)propanoic acid;3-Chloro-4-hydroxybenzenepropanoic acid;3-(3-Chloro-4-hydroxy-phenyl)-propionic acid

Chemical Property of 3-(3-chloro-4-hydroxyphenyl)propanoic acid

Chemical Property:

• PSA: 57.53000
• LogP: 2.06280

Purity/Quality:

98%Min ^*data from raw suppliers

3-(3-chloro-4-hydroxyphenyl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-chloro-4-hydroxyphenyl)propanoic acid

There total 6 articles about 3-(3-chloro-4-hydroxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-(3-chloro-4-hydroxyphenyl)propionic acid ethyl ester (1056009-82-5) → 3-(3-Chloro-4-hydroxyphenyl)propionic acid (79669-18-4)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; Inert atmosphere;

Reference yield:

3-{3-chloro-4-(benzyloxy)phenyl}acrylic acid ethyl ester (868598-89-4) → 3-(3-Chloro-4-hydroxyphenyl)propionic acid (79669-18-4)

Guidance literature:

3-{3-chloro-4-(benzyloxy)phenyl}acrylic acid ethyl ester; With hydrogenchloride; water; hydrogen; platinum on carbon; In ethanol;

With water; hydrogen bromide; In acetic acid; at 80 ℃; for 2h;

Reference yield:

3-Chlor-4-methoxy-zimtsaeure-ethylester (17384-95-1) → 3-(3-Chloro-4-hydroxyphenyl)propionic acid (79669-18-4)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / ethyl acetate / 2 h / 20 °C

2: boron tribromide / dichloromethane / 20 °C / Inert atmosphere

3: sodium hydroxide; water / methanol / 20 °C / Inert atmosphere

With palladium on activated charcoal; water; hydrogen; boron tribromide; sodium hydroxide; In methanol; dichloromethane; ethyl acetate;

upstream raw materials:

2-(3-Chloro-4-methoxy-benzyl)-malonic acid diethyl ester

3-{3-chloro-4-(benzyloxy)phenyl}acrylic acid ethyl ester

3-Chlor-4-methoxy-zimtsaeure-ethylester

3-(3-chloro-4-hydroxyphenyl)propionic acid ethyl ester

Downstream raw materials:

3-{3-chloro-4-(2-propynyloxy)phenyl}propionic acid

methyl 3-(3-chloro-4-hydroxyphenyl)propionate

Refernces

• 1、 -. "AMIDE COMPOUND AND USE OF THE SAME". Page/Page column 51. . Retrieved 2010/02/14.