2-Fluoro-4-(4-methylpiperazin-1-YL)benzaldehyde

Base Information

• Chemical Name: 2-Fluoro-4-(4-methylpiperazin-1-YL)benzaldehyde
• CAS No.: 1197193-42-2
• Molecular Formula: C12H15FN2O
• Molecular Weight: 222.262
• DSSTox Substance ID: DTXSID00693895
• Wikidata: Q82622875
• Mol file: 1197193-42-2.mol

Synonyms:1197193-42-2;2-FLUORO-4-(4-METHYLPIPERAZIN-1-YL)BENZALDEHYDE;2-FLUORO-4-(4-METHYL-1-PIPERAZINYL)BENZALDEHYDE;MFCD13191597;SCHEMBL15448633;DTXSID00693895;AMY20187;AKOS015904332;AS-31529;SY006891;CS-0321218;FT-0747667;A892444;Benzaldehyde, 2-fluoro-4-(4-methyl-1-piperazinyl)-

Chemical Property of 2-Fluoro-4-(4-methylpiperazin-1-YL)benzaldehyde

Chemical Property:

• PSA: 23.55000
• LogP: 1.39290
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 222.11684127
• Heavy Atom Count: 16
• Complexity: 241

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-4-(4-methylpiperazin-1-yl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)C2=CC(=C(C=C2)C=O)F

Technology Process of 2-Fluoro-4-(4-methylpiperazin-1-YL)benzaldehyde

There total 1 articles about 2-Fluoro-4-(4-methylpiperazin-1-YL)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,4-difluorobenzaldehyde (1550-35-2) + N-methylpiperazine dihydrochloride (50398-09-9,51545-09-6,34352-59-5) → 2-fluoro-4-(4-methylpiperazin-1-yl)benzaldehyde (1197193-42-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 120 ℃; for 2h;

DOI:10.1021/jm300952s

Reference yield: 31.0%

2-fluoro-4-(4-methylpiperazin-1-yl)benzaldehyde (1197193-42-2) + 3-(4-(4-(4-methylpiperazin-1-yl)butoxy)phenyl)thiazolidine-2,4-dione → (Z)-5-(2-fluoro-4-(4-methylpiperazin-1-yl)benzylidene)-3-(4-(4-(4-methylpiperazin-1-yl)butoxy)phenyl)thiazolidine-2,4-dione

Guidance literature:

With sodium acetate; acetic acid; at 110 ℃; for 16h;

DOI:10.1016/j.bioorg.2019.103261

Reference yield: 27.0%

5-chloro-4-[4-(5-methyl-isoxazol-3-ylmethyl)piperazin-1-yl]-3-nitro-pyridin-2-ylamine (942949-34-0) + 2-fluoro-4-(4-methylpiperazin-1-yl)benzaldehyde (1197193-42-2) → 3-((4-(6-chloro-2-(2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole (1402709-70-9)

Guidance literature:

With sodium dithionite; In ethanol; water; for 24h; Reflux;

DOI:10.1021/jm300952s

upstream raw materials:

2,4-difluorobenzaldehyde

N-methylpiperazine dihydrochloride

Downstream raw materials:

3-((4-(6-chloro-2-(2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1197193-42-2 2-Fluoro-4-(4-methylpiperazin-1-yl)benzaldehyde

Send

Send

Metric Ton KG G Pound L ML

Send

Send