10-(CYANOMETHYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID

Base Information

Chemical Name:10-(CYANOMETHYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID
CAS No.:643743-39-9
Molecular Formula:C₁₅H₁₁FN₂O₄
Molecular Weight:302.262
Hs Code.:
Mol file:643743-39-9.mol

Synonyms:9-CYANOMETHYL-8-FLUORO-3-METHYL-6-OXO-2,3-DIHYDRO-6H-1-OXA-3A-AZA-PHENALENE-5-CARBOXYLIC ACID;10-(CYANOMETHYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID;10-(Cyanomethyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

Suppliers and Price of 10-(CYANOMETHYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
9-CYANOMETHYL-8-FLUORO-3-METHYL-6-OXO-2,3-DIHYDRO-6H-1-OXA-3A-AZA-PHENALENE-5-CARBOXYLIC ACID 95.00%
5G
$ 1855.51

Total 7 raw suppliers

Chemical Property of 10-(CYANOMETHYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID

Chemical Property:

PSA：92.32000
LogP:1.85828

Purity/Quality:

99% ^*data from raw suppliers

9-CYANOMETHYL-8-FLUORO-3-METHYL-6-OXO-2,3-DIHYDRO-6H-1-OXA-3A-AZA-PHENALENE-5-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 10-(CYANOMETHYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID

There total 2 articles about 10-(CYANOMETHYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: ethyl (3S)-10-(2-tert-butoxy-1-cyano-2-oxoethyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate

: 176760-98-8,643743-39-9
(3S)-10-(cyanomethyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

Guidance literature:: With sulfuric acid; water; acetic acid; at 110 ℃; for 5h;
DOI:10.1016/j.jfluchem.2018.01.007

Reference yield:

: 106939-34-8
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate

: 176760-98-8,643743-39-9
(3S)-10-(cyanomethyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 4 h / 70 °C

2: sulfuric acid; acetic acid; water / 5 h / 110 °C

With sulfuric acid; water; potassium carbonate; acetic acid; In dimethyl sulfoxide;
DOI:10.1016/j.jfluchem.2018.01.007